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Where the minor things are: a pan-eukaryotic survey suggests neutral processes may explain much of minor intron evolution.
Nucleic Acids Res
November 2023
Department of Molecular and Cell Biology, University of California Merced, Merced, CA 95343, USA.
Spliceosomal introns are gene segments removed from RNA transcripts by ribonucleoprotein machineries called spliceosomes. In some eukaryotes a second 'minor' spliceosome is responsible for processing a tiny minority of introns. Despite its seemingly modest role, minor splicing has persisted for roughly 1.
View Article and Find Full Text PDFFunctionalising the wavefunction.
Stud Hist Philos Sci
December 2022
University of Bristol, Department of Philosophy, Cotham House, BS6 6JL, UK. Electronic address:
Functionalism is the view that being x is to play the role of x. This paper defends a functionalist account of three-dimensional entities in the context of Wave Function Realism (WFR), that can explain in details how we can recover three-dimensional entities out of the wavefunction. In particular, the essay advocates for a novel version of WFR in terms of a functional reductionist approach in the style of David Lewis.
View Article and Find Full Text PDFInterrater reliability estimators tested against true interrater reliabilities.
BMC Med Res Methodol
August 2022
Department of Communication, Faculty of Social Sciences, University of Macau, Taipa, Macao.
Background: Interrater reliability, aka intercoder reliability, is defined as true agreement between raters, aka coders, without chance agreement. It is used across many disciplines including medical and health research to measure the quality of ratings, coding, diagnoses, or other observations and judgements. While numerous indices of interrater reliability are available, experts disagree on which ones are legitimate or more appropriate.
View Article and Find Full Text PDFFrom Something Old to Something New: Functionalist Lessons for the Cognitive Science of Scientific Creativity.
Front Psychol
January 2022
Biological Psychology and Neuroergonomics, Technische Universität Berlin, Berlin, Germany.
An intuitive view is that creativity involves bringing together what is already known and familiar in a way that produces something new. In cognitive science, this intuition is typically formalized in terms of computational processes that combine or associate internally represented information. From this computationalist perspective, it is hard to imagine how non-representational approaches in embodied cognitive science could shed light on creativity, especially when it comes to abstract conceptual reasoning of the kind scientists so often engage in.
View Article and Find Full Text PDFReasons to remember: A functionalist view on the relation between memory and psychopathology.
Curr Opin Psychol
October 2021
Centre for the Psychology of Learning and Experimental Psychopathology, Faculty of Psychology and Educational Sciences, KU Leuven, Leuven, Belgium. Electronic address:
Memory is under investigation as one of the core mechanisms of psychopathology. The traditional cognitive view of memory as a stable structure with a range of set characteristics can be complemented with a perspective that considers remembering as a behaviour that varies fluidly across contexts. Remembering may serve adaptation to the environment by fulfilling a directive function, a self-function and a social function.
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