AI Article Synopsis
- The study explores how chloro-substituted alkynes undergo intramolecular carbolithiation to form exocyclic alkylidene carbenoids, which exhibit both nucleophilic and electrophilic properties.
- A specific stereoselective reaction known as 5-exo-dig addition is the primary outcome, suggesting a preference in the formation process.
- This selectivity is likely influenced by a significant interaction between lithium and chlorine that occurs prior to reaching the transition state.
Article Abstract
The intramolecular carbolithiation of a series of chloro-substituted alkynes leads to exocyclic alkylidene carbenoids of which both nucleophilic and electrophilic characters can be drove. A sole stereoselective 5-exo-dig addition takes place, probably because of a strong and persisting Li-Cl interaction arising before the transition state.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/chem.201403605 | DOI Listing |
Publication Analysis
Top Keywords
chloro-substituted alkynes
8
carbolithiation chloro-substituted
4
alkynes access
4
access vinyl
4
vinyl carbenoids
4
carbenoids intramolecular
4
intramolecular carbolithiation
4
carbolithiation series
4
series chloro-substituted
4
alkynes leads
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!