Background: Anterior temporal lobectomy (ATL) is the most common surgical treatment for temporal lobe epilepsy (TLE), although long-term prognosis is often less favorable than short-term outcomes. This study aimed to examine the outcomes of patients with TLE 5 years after undergoing ATL, and to seek possible predictors of prognosis.
Methods: We examined the clinical records of 121 patients with TLE who underwent ATL in our institution between January 2005 and December 2008. The Engel seizure classification was used to divide patients into "seizure free" and "non-seizure free" groups. Univariate and multivariate Logistic regression analyses were used to identify potential prognostic indicators, including history, clinical features of seizures, and magnetic resonance imaging (MRI) and video-electroencephalography (EEG) findings.
Results: The majority of patients were seizure free during the follow-up period: 71.9% 1 year after surgery; 71.6% after 2 years; 75.8% after 3 years; 78.8% after 4 years after surgery and 68.8% after 5 years. There were significant differences between seizure-free and non-seizure-free groups in terms of preoperative seizure duration, history of febrile seizures, type of seizure, and MRI and video-EEG findings (P < 0.05), but not in terms of sex, age at seizure onset, age at surgery, side of surgery, auras, family history of seizure, or history of traumatic brain injury, perinatal anoxia or intracranial infection history (P > 0.05). Multivariate Logistic regression analysis showed that a preoperative seizure duration <10 years, a history of febrile seizures, simple complex partial seizures, positive MRI findings, hippocampal sclerosis and unilateral localized video-EEG spikes predicted better outcome (P < 0.05).
Conclusions: ATL appears to be an effective means of treating TLE. Patients undergoing ATL for TLE require careful and comprehensive assessment to ensure optimal outcomes and to allow patients to make informed decisions about their treatment.
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Clin Radiol
December 2024
Department of Neurology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China. Electronic address:
Aim: To provide a theoretical basis for the study of the pathogenesis of residual dizziness (RD) from the perspective of imaging.
Materials And Methods: The general clinical data of the RD group and healthy control (HC) group were statistically analysed by two independent sample t tests, rank sum tests or chi-square tests. The imaging data of the two groups of people were preprocessed and statistically analysed by using the data processing and analysis for brain imaging (DPABI) software package.
J Neurosurg
January 2025
Departments of1Biomedical Engineering.
Objective: Epilepsy is a common neurological disease affecting nearly 1% of the global population, and temporal lobe epilepsy (TLE) is the most common type. Patients experience recurrent seizures and chronic cognitive deficits that can impact their quality of life, ability to work, and independence. These cognitive deficits often extend beyond the temporal lobe and are not well understood.
View Article and Find Full Text PDFJ Neurosurg
January 2025
1Service de Neurochirurgie, Université de Lorraine, CHRU-Nancy.
Objective: Recent voxel-based lesion symptom mapping (VLSM) studies have identified a critical region for picture naming, located 3.4 to 6.1 cm from the temporal pole.
View Article and Find Full Text PDFBrain
January 2025
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37240, USA.
Resective epilepsy surgery can be an effective treatment for patients with medication-resistant focal epilepsy. Epilepsy resection consists of the surgical removal of an epileptic focus to stop seizure generation and disrupt the epileptic network. However, even focal surgical resections for epilepsy lead to widespread brain network changes.
View Article and Find Full Text PDFBrain Imaging Behav
January 2025
School of Medicine, Pusan National University, Yangsan, Republic of Korea.
COVID-19 disease, caused by the SARS-CoV-2 virus, has significantly altered modern society and lifestyles. We investigated its impact on brain glucose metabolism by meta-analyzing existing studies that utilized 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) scans of the brain. We conducted a systematic search of MEDLINE and EMBASE databases from inception to August 2024 for English-language publications using the keywords "positron emission tomography", and "COVID-19".
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