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Daptomycin treatment for persistent bacteremia in a pediatric solid organ transplant recipient: Case report and literature review.
J Infect Chemother
August 2024
Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan; Department of Pediatrics, Hamamatsu University School of Medicine, Shizuoka, Japan. Electronic address:
Article Synopsis
- The text discusses the limited information on the use of daptomycin for treating persistent bacteremia in pediatric patients, especially those who have undergone solid organ transplantation.
- It presents a case study of an eight-year-old girl whose persistent bacteremia, caused by Staphylococcus epidermidis, was successfully treated with daptomycin after adjusting the dosage due to her renal dysfunction.
- A literature review revealed very few cases of daptomycin use in children with persistent bacteremia, emphasizing the need for more research on its clinical efficacy and pharmacokinetics in this special patient group.
Clinical Features and Genomic Epidemiology of Bloodstream Infections due to Enterococcal Species Other Than or in Patients With Cancer.
Open Forum Infect Dis
June 2024
Division of Infectious Diseases, Department of Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Article Synopsis
- * A study of 70 patients revealed that over half had hematological malignancies, with most infections originating from abdominal sources, and a notable 23% mortality rate within 30 days.
- * Genetic analysis showed diverse NFF strains, low levels of resistance to ampicillin and daptomycin, and higher resistance genes in patients with hematologic cancers compared to those with solid tumors.
Non-canonical amino acid bioincorporation into antimicrobial peptides and its challenges.
J Pept Sci
June 2024
University of New South Wales, Kensington, New South Wales, Australia.
The rise of antimicrobial resistance and multi-drug resistant pathogens has necessitated explorations for novel antibiotic agents as the discovery of conventional antibiotics is becoming economically less viable and technically more challenging for biopharma. Antimicrobial peptides (AMPs) have emerged as a promising alternative because of their particular mode of action, broad spectrum and difficulty that microbes have in becoming resistant to them. The AMPs bacitracin, gramicidin, polymyxins and daptomycin are currently used clinically.
View Article and Find Full Text PDFDevelopment of VRE meningitis due to haematogenous spread while on high-dose daptomycin therapy.
JAC Antimicrob Resist
December 2023
Department of Internal Medicine, Division of Infectious Diseases, University of Arkansas for Medical Sciences, 4301 W Markham Slot #639, Little Rock, AR, USA72205-7101.
Introduction: Vancomycin-resistant (VRE) meningitis accounts for only 0.3%-4.0% of bacterial meningitis cases and typically occurs following neurosurgical intervention.
View Article and Find Full Text PDFFactors influencing on-resin depsipeptide bond formation: case studies on daptomycin- and brevicidine-derived sequences.
Org Biomol Chem
May 2023
School of Chemical Science, School of Biological Sciences, Maurice Wilkins Centre for Biodiscovery, The University of Auckland, Auckland, 1021, New Zealand.
Depsipeptides are an important class of bioactive natural products, where a growing number of genome-mined structures that display anti-microbial activity are macrocyclic depsipeptides. Chemically, peptide ester (depsipeptide) bond formation often displays low yields, and thereby hampers efforts to access these structures for structure-activity studies. Herein, we present a systematic study of the variables that influence depsipeptide bond formation on-resin, using simplified sequences derived from antibiotic peptides, daptomycin and brevicidine, prepared Fmoc-based solid-phase synthesis.
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