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Telacebec Interferes with Virulence Lipid Biosynthesis Protein Expression and Sensitizes to Other Antibiotics.
Microorganisms
September 2023
School of Nursing and Health, Nanfang College Guangzhou, Guangzhou 510970, China.
Tuberculosis (TB), caused by (Mtb), remains a public health issue, particularly due to multi-drug-resistant Mtb. The bacillus is wrapped in a waxy envelope containing lipids acting as essential virulence factors, accounting for the natural antibiotic resistance of mycobacteria. Telacebec (previously known as Q203) is a promising new anti-TB agent inhibiting the cytochrome complex of a mycobacterial electron transport chain (ETC).
View Article and Find Full Text PDFIron deprivation enhances transcriptional responses to growth arrest of .
Front Microbiol
October 2022
Department of Preventive Medicine and Public Health and Microbiology, School of Medicine, Autonomous University of Madrid, Madrid, Spain.
The establishment of (Mtb) long-term infection depends on several factors, one of which is the availability of key nutrients such as iron (Fe). The relation between Fe deprivation inside and outside the granuloma, and the capacity of Mtb to accumulate lipids and persist in the absence of growth is not well understood. In this context, current knowledge of how Mtb modifies its lipid composition in response to growth arrest, depending on iron availability, is scarce.
View Article and Find Full Text PDFRv0180c contributes to Mycobacterium tuberculosis cell shape and to infectivity in mice and macrophages.
PLoS Pathog
November 2021
Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France.
Mycobacterium tuberculosis, the main causative agent of human tuberculosis, is transmitted from person to person via small droplets containing very few bacteria. Optimizing the chance to seed in the lungs is therefore a major adaptation to favor survival and dissemination in the human population. Here we used TnSeq to identify genes important for the early events leading to bacterial seeding in the lungs.
View Article and Find Full Text PDFReductive Power Generated by Through Cholesterol Oxidation Contributes to Lipid and ATP Synthesis.
Front Cell Infect Microbiol
August 2021
Laboratório de Microbiologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Upon infection, , an obligate intracellular bacillus, induces accumulation of cholesterol-enriched lipid droplets (LDs) in Schwann cells (SCs). LDs are promptly recruited to -containing phagosomes, and inhibition of this process decreases bacterial survival, suggesting that LD recruitment constitutes a mechanism by which host-derived lipids are delivered to intracellular . We previously demonstrated that has preserved only the capacity to oxidize cholesterol to cholestenone, the first step of the normal cholesterol catabolic pathway.
View Article and Find Full Text PDFMethyl-accepting chemotaxis like Rv3499c (Mce4A) protein in Mycobacterium tuberculosis H37Rv mediates cholesterol-dependent survival.
Tuberculosis (Edinb)
March 2018
Department of Microbiology, V. P. Chest Institute, University of Delhi, Chatra Marg, Delhi, 110007, India. Electronic address:
Cholesterol, an essential cellular component in macrophages, is exploited for entry and long-term survival of Mycobacterium inside the host. Cholesterol-deficient macrophages can restrict the cholesterol-dependent entry of Mycobacterium. Rv3499c protein in Mycobacterium has high binding affinity for cholesterol.
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