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AVP-GPT2: A Transformer-Powered Platform for De Novo Generation, Screening, and Explanation of Antiviral Peptides.
Viruses
December 2024
Beijing Youcare Kechuang Pharmaceutical Technology Co., Ltd., Beijing 100176, China.
Human respiratory syncytial virus (RSV) remains a significant global health threat, particularly for vulnerable populations. Despite extensive research, effective antiviral therapies are still limited. To address this urgent need, we present AVP-GPT2, a deep-learning model that significantly outperforms its predecessor, AVP-GPT, in designing and screening antiviral peptides.
View Article and Find Full Text PDFEvaluating the Reliability and Consistency of Treadmill Gait Analysis Using an RGB-D Camera: Effects of Assistance and No Assistance.
Sensors (Basel)
January 2025
College of Sport and Health Science, Ritsumeikan University, Kusatsu 525-8577, Shiga, Japan.
This study aimed to assess the intraday reliability of markerless gait analysis using an RGB-D camera versus a traditional three-dimensional motion analysis (3DMA) system with and without a simulated walking assistant. Gait assessments were conducted on 20 healthy adults walking on a treadmill with a focus on spatiotemporal parameters gathered using the RGB-D camera and 3DMA system. The intraday reliability of the RGB-D camera was evaluated using intraclass correlation coefficients (ICC 1, 1), while its consistency with the 3DMA system was determined using ICC (2, 1).
View Article and Find Full Text PDFSimultaneous Determination of Stilbenes, Flavones, Coumestans, Anthraquinones, and Chalcones in Ethanolic Extract of Pet-Sang-Kard Mixed Herbal Remedy Using HPLC-PDA Analysis.
Molecules
January 2025
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
The Pet-Sang-Kard mixed herbal remedy (PSKMHR) is a traditional Thai medicinal formulation used as an herbal supplement for the treatment of hemorrhoids. This remedy consists of four specific herbal ingredients in the following proportions: 50 parts L. stems, 15 parts L.
View Article and Find Full Text PDFProbiotic Therapy as an Adjuvant in the Treatment of Periodontal Disease: An Innovative Approach.
Medicina (Kaunas)
January 2025
Department of Dental Medicine, Faculty of Medicine and Pharmacy, University of Oradea, 10 1st Decembrie Street, 410073 Oradea, Romania.
: Periodontal inflammation, often linked to oral microbiota dysbiosis dominated by pathogenic bacteria, remains a significant challenge in periodontitis management. Traditional periodontal therapies primarily reduce the bacterial load but fail to restore the microbiota balance. Probiotics offer a promising therapeutic adjunct with their ability to enhance beneficial bacteria.
View Article and Find Full Text PDFA longitudinal blended learning curriculum for bedside ultrasound education in pulmonary and critical care fellowship.
BMC Med Educ
January 2025
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA.
Background: There exists no standardized longitudinal curriculum for teaching bedside ultrasonography (US) in Pulmonary and Critical Care Medicine (PCCM) fellowship programs. Given the importance of mastering bedside US in clinical practice, we developed an integrated year-long US curriculum for first-year PCCM fellows.
Methods: 11 first-year PCCM fellows completed the entire seven-step Blended Learning Curriculum.
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