Background: Although short-term outcomes of reverse total shoulder arthroplasty have been promising, long-term success may be limited due to device-specific complications, including scapular notching. Scapular notching has been explained primarily as mechanical erosion; however, the generation of wear debris may lead to further biologic changes contributing to the severity of scapular notching.
Methods: A 12-station hip simulator was converted to a reverse total shoulder arthroplasty wear simulator subjecting conventional and highly cross-linked ultra-high-molecular-weight polyethylene humeral liners to 5 million cycles of alternating abduction-adduction and flexion-extension loading profiles.
Results: Highly cross-linked polyethylene liners (36.5 ± 10.0 mm(3)/million cycle) exhibited significantly lower volumetric wear rates compared with conventional polyethylene liners (83.6 ± 20.6 mm(3)/million cycle; P < .001). The flexion-extension loading profile exhibited significantly higher wear rates for conventional (P < .001) and highly cross-linked polyethylene (P < .001) compared with the abduction-adduction loading profile. Highly cross-linked wear particles had an equivalent circle diameter significantly smaller than wear particles from conventional polyethylene (P < .001).
Conclusions: Highly cross-linked polyethylene liners significantly reduced polyethylene wear and subsequent particle generation. More favorable wear properties with the use of highly cross-linked polyethylene may lead to increased device longevity and fewer complications but must be weighed against the effect of reduced mechanical properties.
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http://dx.doi.org/10.1016/j.jse.2014.05.001 | DOI Listing |
J Biomater Sci Polym Ed
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School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior, India.
Ulcerative colitis, a chronic inflammatory condition of the colon, requires precise and targeted treatment, and polysaccharides, with their pH responsiveness and biodegradability, offer an innovative approach for colon-specific drug delivery. This study aims to develop a highly precise drug delivery system with enhanced therapeutic and targeting efficiency for ulcerative colitis, focusing on the preparation, optimisation, and evaluation of dual cross-linked mesalamine-loaded sericin-pectin (DSPs) micro-beads. These beads utilise the pH-responsive and microflora biodegradability properties of polysaccharides for targeted colon delivery, employing the Response Surface Methodology.
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Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China; College of Materials Science and Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address:
Graphene exhibits exceptional electrical properties, and aerogels made from it demonstrate high sensitivity when used in sensors. However, traditional graphene aerogels have poor biocompatibility and sustainability, posing potential environmental and health risks. Moreover, the stacking of their internal structures results in low compressive strength and fatigue resistance, which limits their further applications.
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Department of Orthopaedic Surgery, University of Utah, Salt Lake City, Utah.
Mater Today Bio
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Department of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111, Budapest, Hungary.
Mucosal membranes with strong variability in their viscoelastic properties line numerous organs and are often targeted by mucoadhesive formulations, e.g., highly swellable hydroxypropylmethylcellulose (HPMC) and slightly cross-linked poly(acrylic acid) (PAA) tablets.
View Article and Find Full Text PDFBiomater Sci
January 2025
Department of Biological Sciences and Engineering Indian Institute of Technology, Palaj, Gandhinagar 382355, India.
The application of nanotechnology in medical biology has seen a significant rise in recent years because of the introduction of novel tools that include supramolecular systems, complexes, and composites. Dendrimers are one of the remarkable examples of such tools. These spherical, regularly branching structures with enhanced cell compatibility and bioavailability have shown to be an excellent option for gene or drug administration.
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