A study of cardiovascular miRNA biomarkers for Kawasaki disease.

Anne H Rowley Adam J Pink Rebecca Reindel Nancy Innocentini Susan C Baker Stanford T Shulman Kwang-Youn A Kim

Pediatr Infect Dis J

From the *Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL; †Department of Microbiology/Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL; ¶Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL; ‡Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL; and §Department of Microbiology/Immunology, Loyola University Stritch School of Medicine, Maywood, IL.

Published: December 2014

We hypothesized that cardiovascular miRNAs might be diagnostic biomarkers for Kawasaki disease (KD). We identified dysregulated miRNAs in KD coronary arteries, and tested sera from KD patients and febrile controls for cardiovascular miRNAs using 2 methods. We did not identify cardiovascular miRNAs diagnostic for KD; our results may help guide future studies of potential miRNA biomarkers for KD.

Download full-text PDF	Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229439	PMC
http://dx.doi.org/10.1097/INF.0000000000000449	DOI Listing

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