Anti-proliferative activity of 6-O-acyl-D-allose against the human leukemia MOLT-4F cell line.

Biosci Biotechnol Biochem

a Faculty of Agriculture, Department of Applied Biological Science , Kagawa University, Miki-cho , Kagawa , 761-0795 , Japan.

Published: March 2015

The anti-proliferative activities of the 6-O-acyl derivatives of D-allose against the human leukemia MOLT-4F cell line were examined. The activity of the 6-O-dodecanoyl derivative (3) was approximately 30 times stronger than that of D-allose. An evaluation of the derivatives of 3 that occurred in a furanose form revealed the pyranose forms of 3 to be important for the anti-proliferative activity.

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http://dx.doi.org/10.1080/09168451.2014.882747DOI Listing

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