AI Article Synopsis
- The study investigates the relationship between brucellosis and oxidative stress, comparing patients with brucellosis to healthy controls to assess levels of free radicals and antioxidants.
- Findings indicate that patients had higher levels of ceruloplasmin and total antioxidant capacity compared to the control group, while their oxidative stress index was significantly lower.
- The results suggest that brucellosis disrupts the balance between oxidants and antioxidants, which could be important for monitoring the disease and evaluating treatment outcomes in affected individuals.
Article Abstract
Unlabelled: It is possible that brucellosis may be related to increase free radical production and antioxidant depletion. Thus, in the present study we aimed to evaluate the oxidative status in patient with brucellosis and healthy controls.
Methods: This study includes the patients with brucellosis diagnosed by clinical findings and positive agglutination titer. The paraoxonase, ceruloplasmin, total antioxidant capacity and total oxidant status values were measured from the samples taken. The oxidative stress index value was calculated through the total antioxidant capacity and total oxidant status values.
Results: A total number of 93 people, 40 women (43%) and 53 men (57%) were included to the study. The levels of ceruloplasmin were found higher in patients when compared to the control group (p < 0.001). The total antioxidant capacity level was found significantly higher in the patients group when compared to the control group (p < 0.001). The oxidative stress index value was significantly lower in the patients group when compared to the control group (p < 0.001). The paraoxonase-1 level was not different in control and patient groups (p = 0.077).
Conclusions: Brucellosis is an infection that is frequently seen in Mediterranean countries. This infection breaks the oxidant and antioxidant balance. In this disease, oxidant-antioxidant system indicators such as ceruloplasmin, total antioxidant capacity, total oxidant status and oxidative stress index can be used for showing the role of the brucella infection and for the monitoring of the treatment results.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100970 | PMC |
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