Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097905 | PMC |
| http://dx.doi.org/10.4103/0973-6131.133934 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Safety of Deutetrabenazine for the Treatment of Tardive Dyskinesia and Chorea Associated with Huntington Disease.
Neurol Ther
June 2024
Teva Branded Pharmaceutical Products R&D, Inc., West Chester, PA, USA.
Introduction: Deutetrabenazine is a vesicular monoamine transporter 2 inhibitor used to treat tardive dyskinesia (TD) and chorea associated with Huntington disease (HD). To enhance detection of safety signals across individual trials, integrated safety analyses of deutetrabenazine in TD and HD chorea were conducted.
Methods: For TD, safety data were integrated from two 12-week pivotal studies (ARM-TD and AIM-TD) and through week 15 of the open-label extension (OLE) study (RIM-TD).
Effects of cortisol administration on heart rate variability and functional connectivity across women with different depression histories.
Behav Brain Res
April 2024
Department of Psychiatry, University of Wisconsin-Madison, University of Wisconsin-Madison, 6001 Research Park Blvd, Madison, WI 53719, USA; Center for Healthy Minds, University of Wisconsin-Madison., 625 W. Washington Ave, Madison, WI 53703, USA.
Abnormalities within the hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system have been implicated in depression. Studies have reported glucocorticoid insensitivity and reduced heart rate variability (HRV) in depressive disorders. However, little is known about the effects of cortisol on HRV and resting-state functional connectivity (rsFC) of the central autonomic network (CAN) in depression.
View Article and Find Full Text PDFSafety and efficacy of laquinimod for Huntington's disease (LEGATO-HD): a multicentre, randomised, double-blind, placebo-controlled, phase 2 study.
Lancet Neurol
March 2024
Research and Development, Teva Pharmaceutical Industries, Petah Tikva, Israel.
Background: Laquinimod modulates CNS inflammatory pathways thought to be involved in the pathology of Huntington's disease. Studies with laquinimod in transgenic rodent models of Huntington's disease suggested improvements in motor function, reduction of brain volume loss, and prolonged survival. We aimed to evaluate the safety and efficacy of laquinimod in improving motor function and reducing caudate volume loss in patients with Huntington's disease.
View Article and Find Full Text PDFDown-regulation of iron/zinc ion transport and toxin synthesis in Microcystis aeruginosa exposed to 5,4'-dihydroxyflavone.
J Hazard Mater
October 2023
Ocean College, Zhejiang University, 1 Zheda Road, Zhoushan, Zhejiang 316021, China; Key Laboratory of Marine Ecological Monitoring and Restoration Technologies of the Ministry of Natural Resources of China, Shanghai 201206, China; Donghai Laboratory, Zhoushan, Zhejiang 316021, China; Key Laboratory of Watershed Non-point Source Pollution Control and Water Eco-security of Ministry of Water Resources, College of Environmental and Resources Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address:
Flavonoids, common natural polyphenolic compounds from plants, have been proposed as highly effective and safe algicides. However, the molecular mechanism of flavonoids inhibiting Microcystis aeruginosa remains unclear. This study aims in exploring the global transcriptional changes and molecular docking in cyanobacterial cells in response to flavonoids.
View Article and Find Full Text PDFPrana is the driving and organizing force of the entire universe, and essential for survival. It can be experimental and experiential. This is a retrospective analysis of the pranic energy perception data collected for an exploratory study conducted in 2014 using the convenience sampling method.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!