Dysfunctional cortical inhibition in adult ADHD: neural correlates in auditory event-related potentials.

J Neurosci Methods

Systems Neuroscience & Neurotechnology Unit, Saarland University, Faculty of Medicine, Neurocenter, Building 90.5, D-66421 Homburg/Saar, Germany; Saarland University of Applied Sciences, School of Engineering, Technikum, D-66117 Saarbrücken, Germany; Leibniz-Institut for New Materials, Campus D2 2, D-66123 Saarbrücken, Germany; Key Numerics - Medical Engineering, D-66129 Saarbrücken, Germany. Electronic address:

Published: September 2014

In recent times, the relevance of an accurate diagnosis of attention-deficit/hyperactivity disorder (ADHD) in adults has been the focus of several studies. No longer considered a pathology exclusive to children and adolescents, and taking into account its social implications, developing enhanced support tools for the current diagnostic procedure becomes a priority. Here we present a method for the objective assessment of ADHD in adults using chirp-evoked, paired auditory late responses (ALRs) combined with a two-dimensional ALR denoising scheme to extract correlates of intracortical inhibition. Our method allows for an effective single-sweep denoising, thus requiring less trials to obtain recognizable physiological features, useful as pointers of cortical impairment. Results allow an optimized diagnosis, reduction of data loss and acquisition time; moreover, they do not account exclusively for critical elements within clinical evaluations, but also allow studying the pathophysiology of the condition by providing objective information regarding impaired cortical functions.

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http://dx.doi.org/10.1016/j.jneumeth.2014.06.025DOI Listing

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