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Comparative characteristics of genetic aberrations in glioblastomas in children and adults. | LitMetric
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Comparative characteristics of genetic aberrations in glioblastomas in children and adults.

M V Ryzhova L V Shishkina O G Zheludkova A V Golanov S K Gorelyshev D I Pitskhelauri A Kh Bekiashev G L Kobiakov O V Absaliamova R V Sycheva A G Korshunov

Zh Vopr Neirokhir Im N N Burdenko

Published: August 2014

Glioblastomas in children and adults are a heterogeneous group of tumors that can be divided into at least three different subgroups: pediatric glioblastomas, IDH1-mutant glioblastomas in adults (the most favorable prognostic subtype), and IDH1-wild type glioblastomas in adults. According to the frequency of detected cytogenetic aberrations (amplification of the MYC/MYCN, EGFR and PDGRFA oncogenes, homozygous deletion of the CDKN2A gene, and deletion of the PTEN gene), pediatric glioblastomas bear analogy to the subgroup of IDH1-mutant glioblastomas in adults.

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