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The connectome describes the complete set of synaptic contacts through which neurons communicate. While the architecture of the $\textit{C. elegans}$ connectome has been extensively characterized, much less is known about the organization of causal signaling networks arising from functional interactions between neurons.
View Article and Find Full Text PDFUnlabelled: Inadequate response to androgen deprivation therapy (ADT) frequently arises in prostate cancer, driven by cellular mechanisms that remain poorly understood. Here, we integrated single-cell RNA sequencing, single-cell multiomics, and spatial transcriptomics to define the transcriptional, epigenetic, and spatial basis of cell identity and castration response in the mouse prostate. Leveraging these data along with a meta-analysis of human prostates and prostate cancer, we identified cellular orthologs and key determinants of ADT response and resistance.
View Article and Find Full Text PDFChanges in seasonal influenza vaccination uptake among older adults during and after the COVID-19 pandemic: Repeated random telephone surveys.
Hum Vaccin Immunother
December 2025
Centre for Health Behavious Research, Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.
People's risk of contracting seasonal influenza increased after COVID-19 control measures were relaxed. This study investigated the changes in seasonal influenza vaccination (SIV) uptake and its determinants among older adults during and after the COVID-19 period. Two rounds of random telephone surveys were conducted among 440 and 373 community-living individuals aged ≥65 y, the first between November 2021 and January 2022 and the second between October 2023 and January 2024.
View Article and Find Full Text PDFBehavioral intention to receive self-financed and fully-subsidized herpes zoster vaccines among community-living older adults in Hong Kong: A random telephone survey.
Hum Vaccin Immunother
December 2025
Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Herpes zoster (HZ) among older adults has consistently been a concern. Despite the availability of vaccines, HZ vaccination remains underutilized globally. This study investigated the behavioral intention of older adults in Hong Kong to receive self-financed or fully subsidized HZ vaccines.
View Article and Find Full Text PDFMachine learning-based estimation of crude oil-nitrogen interfacial tension.
Sci Rep
January 2025
Young Researchers and Elite Club, Omidiyeh Branch, Islamic Azad University, Omidiyeh, Iran.
Accurate estimation of interfacial tension (IFT) between nitrogen and crude oil during nitrogen-based gas injection into oil reservoirs is imperative. The previous research works dealing with prediction of IFT of oil and nitrogen systems consider synthetic oil samples such n-alkanes. In this work, we aim to utilize eight machine learning methods of Decision Tree (DT), AdaBoost (AB), Random Forest (RF), K-nearest Neighbors (KNN), Ensemble Learning (EL), Support Vector Machine (SVM), Convolutional Neural Network (CNN) and Multilayer Perceptron Artificial Neural Network (MLP-ANN) to construct data-driven intelligent models to predict crude oil - nitrogen IFT based upon experimental data of real crude oils samples encountered in underground oil reservoirs.
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