The tyrosine-protein kinase Tec (TEC) is a member of non-receptor tyrosine kinases and has critical roles in cell signaling transmission, calcium mobilization, gene expression, and transformation. TEC is also involved in various immune responses, such as mast cell activation. Therefore, we hypothesized that TEC polymorphisms might be involved in aspirin-exacerbated respiratory disease (AERD) pathogenesis. We genotyped 38 TEC single nucleotide polymorphisms in a total of 592 subjects, which comprised 163 AERD cases and 429 aspirin-tolerant asthma controls. Logistic regression analysis was performed to examine the associations between TEC polymorphisms and the risk of AERD in a Korean population. The results revealed that TEC polymorphisms and major haplotypes were not associated with the risk of AERD. In another regression analysis for the fall rate of forced expiratory volume in 1 second (FEV1) by aspirin provocation, two variations (rs7664091 and rs12500534) and one haplotype (TEC_BL2_ht4) showed nominal associations with FEV1 decline (p = 0.03-0.04). However, the association signals were not retained after performing corrections for multiple testing. Despite TEC playing an important role in immune responses, the results from the present study suggest that TEC polymorphisms do not affect AERD susceptibility. Findings from the present study might contribute to the genetic etiology of AERD pathogenesis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099349 | PMC |
| http://dx.doi.org/10.5808/GI.2014.12.2.58 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Polymorphisms of and Genes and Their Correlation Analysis with Growth Traits in Ashidan Yaks.
Animals (Basel)
December 2024
Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Key Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou 730050, China.
Article Synopsis
- The tyrosine protein kinase gene, part of the Tec family, and phospholipase C epsilon 1 play crucial roles in signal transduction and muscle differentiation, respectively.
- A study explored the impact of SNPs in these genes on growth traits such as body weight and height in Ashidan yaks.
- Significant correlations were found between specific SNP loci and growth characteristics, suggesting potential molecular markers for improving yak breeding.
Investigating p.Ala1035Val in NPC1: New Cellular Models for Niemann-Pick Type C Disease.
Int J Mol Sci
November 2024
Research and Development Unit, Department of Human Genetics, National Institute of Health Doutor Ricardo Jorge (INSA, I. P.), Rua Alexandre Herculano 321, 4000-055 Porto, Portugal.
Article Synopsis
- * The p.Ala1035Val variant is the most common in Portugal and is linked to a potential SNP (p.Ile858Val) that may affect disease progression.
- * Research using in vitro models reveals that the p.Ala1035Val variant, especially when combined with p.Ile858Val, shows decreased lysosomal trafficking similar to p.Ile1061Thr, suggesting the need for new therapeutic approaches.
Genome-wide association and functional annotation analysis for the calving interval in Nellore cattle.
Theriogenology
April 2024
Federal University of Bahia, Animal Science Department, Av. Milton Santos, 500, Ondina, Salvador, BA, 40170-110, Brazil. Electronic address:
Calving interval (CI) measures the number of days between two consecutive calves of the same cow, and previous studies based on phenotype and pedigree data reported low heritability for this trait. However, the genetic architecture of CI in the Nellore breed was not evaluated based on genomic data. Thus, this study aimed to estimate the heritability based on genomic data and carry out a genome-wide association study (GWAS) for CI in the Nellore breed, using 12,599 pedigree records, 5078 CI records, and 3818 animals genotyped with 50k SNPchip panel.
View Article and Find Full Text PDFMulti-omics analyses reveal novel effects of PLCγ2 deficiency in the mouse brain.
bioRxiv
December 2023
Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio.
Article Synopsis
- PLCγ2 plays a key role in breaking down PIP into signaling molecules DAG and IP, which are important for various cellular functions and are linked to Alzheimer's disease risk and longevity.
- Researchers examined the brains of different genotypes of mice (KO, HET, and WT) using multiomics techniques and found sex-specific alterations in lipid content and myelin-related gene expression due to PLCγ2 depletion.
- The study highlights that loss of PLCγ2 leads to subtle changes in microglia and oligodendrocyte density, affecting brain homeostasis and potentially increasing vulnerability to Alzheimer's disease and aging-related issues through previously unknown pathways.
Identification of novel sources of partial and incomplete hypersensitive resistance to rust and associated genomic regions in common bean.
BMC Plant Biol
December 2023
Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB NOVA), Oeiras, 2780-157, Portugal.
Common bean (Phaseolus vulgaris) is one of the legume crops most consumed worldwide and bean rust is one of the most severe foliar biotrophic fungal diseases impacting its production. In this work, we searched for new sources of rust resistance (Uromyces appendiculatus) in a representative collection of the Portuguese germplasm, known to have accessions with an admixed genetic background between Mesoamerican and Andean gene pools. We identified six accessions with incomplete hypersensitive resistance and 20 partially resistant accessions of Andean, Mesoamerican, and admixed origin.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!