A 29-year-old woman with stage IVB Hodgkin's lymphoma was treated with doxorubicin, bleomycin, vinblastine, and dacarbazine. Two weeks after the first cycle was completed, she developed pruritic, linear erythematous lesions in a flagellate-like pattern on the trunk, neck and arms. After oral prednisone therapy and cessation of bleomycin, the lesions started to recede.
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http://dx.doi.org/10.1016/j.bjhh.2014.03.001 | DOI Listing |
J Ayub Med Coll Abbottabad
January 2024
Lahore Medical and Dental College, Lahore-Pakistan.
Med Clin (Barc)
April 2024
Hematology Unit, Department of Medicine, University of Padova, Italy. Electronic address:
A A Pract
October 2023
Department of Anesthesiology and Critical Care Medicine, University of New Mexico, Albuquerque, New Mexico.
Sclerotherapy with bleomycin can cause cosmetic complications, including flagellate dermatitis and hyperpigmentation, induced or exacerbated by microtrauma to the skin. We report a case of a 9-year-old pediatric patient with congenital vascular malformations in which a cohesive bandage (eg, 3M Coban) was utilized to prevent bleomycin-induced hyperpigmentation. Postoperatively and on follow-up, there were no signs of hyperpigmentation or dermatitis in our patient.
View Article and Find Full Text PDFCureus
December 2022
Department of Hematology and Oncology, Mayo Clinic, Jacksonville, USA.
Bleomycin, a cytotoxic antibiotic commonly used as part of combination chemotherapy regimes in the treatment of germ cell tumors, is well known among clinicians for its potential pulmonary toxicity. Less well known, although postulated to occur through a similar pathomechanism, are the wide spectrum of dermatologic adverse reactions associated with bleomycin therapy. The current case report describes the sudden and distressing appearance of a pruritic erythematous flagellate "whip-like" rash in a 30-year-old Caucasian male undergoing treatment for testicular embryonal carcinoma following the second infusion of bleomycin-containing chemotherapy.
View Article and Find Full Text PDFCureus
September 2022
Obstetrics and Gynaecology, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.
Flagellate dermatitis caused by bleomycin is a rare side effect with a distinctive pattern of whip-like, linear streaks. The clinical presentation has become uncommon nowadays as bleomycin use in conventional chemotherapy regimens has decreased. We present a case of a 30-year-old female diagnosed with ovarian germ cell tumour, managed with bleomycin, etoposide, and cisplatin (BEP) and later developed a widespread rash indicative of classic flagellate dermatitis.
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