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Assessment of Helicobacter pylori infection in Lebanon: Endoscopic and histopathological findings.
J Infect Public Health
January 2025
Department of Medical Laboratory Sciences, Faculty of Health Sciences, Beirut Arab University, Beirut 11-5020, Lebanon. Electronic address:
Helicobacter pylori (H. pylori), a pervasive pathobiont, colonizes the gastric mucosa and plays a crucial role in the pathogenesis of several gastroduodenal pathologies ranging from chronic gastritis to more severe disorders including peptic ulcer disease, gastric mucosa-associated lymphoid tissue lymphoma, and gastric adenocarcinoma. In symptomatic patients, endoscopy and histological examination of the gastric mucosa are the preferred tests for diagnosing H.
View Article and Find Full Text PDFCone Beam Online Adaptive Radiation Therapy: A Promising Approach for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma?
Adv Radiat Oncol
February 2025
Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas.
Purpose: Daily online adaptive radiation therapy (oART) opens the opportunity to treat gastric mucosa-associated lymphoid tissue (MALT) lymphoma with a reduced margin. This study reports our early experience of cone beam computed tomography (CBCT)-based daily oART treating gastric MALT lymphoma with breath-hold and reduced margins.
Methods And Materials: Ten patients were treated on a CBCT-based oART system.
Clinical features and temporal trends in H. pylori negative gastric maltoma.
Arab J Gastroenterol
January 2025
Division of Gastroenterology and Hepatology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:
Article Synopsis
- Mucosa-Associated Lymphoid Tissue (MALT) lymphoma, particularly gastric MALToma, is often associated with Helicobacter pylori (H. pylori) infection, though a significant number of cases occur without it.
- A study analyzed 52 patients with gastric MALToma from 2000 to 2021, finding that 48.1% were H. pylori-negative (HPN) and noted trends of increased HPN diagnoses in more recent years.
- Treatment outcomes showed that HPP patients had better responses to eradication therapy compared to HPN patients, who were more likely to receive additional chemo or radiotherapy.
- Despite these differences in treatment response, clinical features between HPP and HPN patients
[Characteristics of Gastric Mucosa-associated Lymphoid Tissue Lymphoma in Korea].
Korean J Gastroenterol
December 2024
Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
The prevalence of gastric mucosa-associated lymphoid tissue (MALT) lymphoma in Korea has not been reported largely because, it is a relatively rare disease. Gastric MALT lymphoma is clinically important because of the high prevalence of () in Korea. The endoscopic findings of gastric MALT lymphoma are diverse, and it is often challenging to differentiate from gastric adenocarcinoma.
View Article and Find Full Text PDFBAFF Blockade Attenuates B Cell MALT Formation in Conditional Nlrc5-Deficient Mice With Helicobacter felis Infection.
Eur J Immunol
December 2024
Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Helicobacter infection is a key cause of gastric B cell mucosa-associated lymphoid tissue (MALT) lymphoma. This study examined the role of B cell-activating factor (BAFF), a major driver of B cell proliferation and many B cell disorders, in this malignancy using a model in which conditional knockout mice for NOD-like receptor family CARD domain-containing 5 (Nlrc5) are infected with Helicobacter felis. Gastric BAFF production was significantly increased in H.
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