[Significance of alanine aminotransferase and reduction of post-transfusion non-A, non-B hepatitis].

To appreciate the test based on the activity of sera alanine aminotransferase (ALT) in the reduction of non-A non-B post-transfusional hepatitis, a study of the variation of this enzyme's activity was done versus several parameters: sex, age and acquired diseases. The population which included 25,813 Parisian blood donors (41.2% of men and 58.8% of women) was divided into two groups: the first was constituted of 25,585 subjects (40.9% of men and 59.1% of women) without clinical etiology and biological diseases, it will be the reference population; the second group was composed of 173 subjects (68.2% of men and 31.8% of women) who had acquired biological markers or clinical diseases during the life. The study within the reference population showed a sexual dimorphism. The study by dispersion diagrams in the population with high seric activity of ALT could explain the causes of blood donors' elimination.