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Computational Psychotherapy System for Mental Health Prediction and Behavior Change with a Conversational Agent.
Neuropsychiatr Dis Treat
December 2024
Department of Intelligent Systems, Jožef Stefan Institute, Ljubljana, Slovenia.
Background: The importance of computational psychotherapy is increasing due to the record high prevalence of mental health issues worldwide. Despite advancements, current computational psychotherapy systems lack advanced prediction and behavior change mechanisms using conversational agents.
Purpose: This work presents a computational psychotherapy system for mental health prediction and behavior change using a conversational agent.
The sensory input, not the motor output, defines blink reflex conditioning.
Clin Neurophysiol
December 2024
Department of Neurorehabilitation, Hospital of Vipiteno (SABES-ASDAA), Vipiteno-Sterzing, Italy; Department of Neurology, Neurocritical Care and Neurorehabilitation, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Paracelsus Medical University, Salzburg, Austria. Electronic address:
Objective: Blink reflexes following supraorbital nerve (SON) stimulation are typically modulated by conditioning stimuli (CS) to the index finger (D2) (low-intensity, prepulse inhibition paradigm) or SON (same intensity, paired-pulse paradigm). We aimed to disentangle whether CS-intensity or CS-induced motor responses define blink reflex modulation.
Methods: In 35 subjects, test SON stimuli (8 times sensory threshold, 8 × ST) were applied either alone or following CS.
Does minimally invasive external fixation of proximal humerus fractures provide adequate stability? A biomechanical in vitro study.
BMC Musculoskelet Disord
October 2024
Institute for Biomechanics, BG Unfallklinik Murnau Professor Küntscher Str. 8, 82418, Murnau, Germany.
Introduction: Proximal humerus fractures are usually treated with rigid angle-stable plates or nails. As an alternative, semi-rigid, minimally invasive systems have been developed for supportive fixation. A new system uses this principle with 2.
View Article and Find Full Text PDFThe gene product (protein PTCD3 or MRPS39) forms the entry channel of the mitochondrial small ribosomal subunit and binds to single-stranded mRNA. Here, we expand on the clinical manifestations of pathogenic variants by describing an early-onset patient with Leigh-like syndrome and two patients with milder form of disease, with combined oxidative phosphorylation deficiency. A 34-year-old male and his 33-year-old sister both have horizontal nystagmus, pronounced rough tremor, truncal ataxia, dysmetria, spasticity and hyperreflexia.
View Article and Find Full Text PDFDual surface modification of polydimethylsiloxane (PDMS) with antithrombin-heparin complex (ATH) and tissue plasminogen activator (t-PA) for enhanced antithrombotic activity.
Biomater Adv
January 2025
School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada; Department of Materials Science & Engineering, McMaster University, Hamilton, ON, Canada. Electronic address:
Article Synopsis
- Medical devices that contact blood can cause clotting and other complications, which is typically managed using anticoagulants and antiplatelet agents, though these can increase bleeding risks.
- A new method investigates coating polydimethylsiloxane (PDMS) surfaces with an antithrombin-heparin complex and tissue plasminogen activator to inhibit clotting and dissolve early clots.
- Different coating processes were tested, and the results showed that a specific sequential application of these agents improved their effectiveness and stability, suggesting potential for better blood compatibility in medical devices.
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