AI Article Synopsis
- The study explores the controversial role of liver transplantation (LT) for cirrhotic patients with tumors that have intrahepatic bile duct characteristics.
- A total of 32 patients were analyzed, revealing varying types of tumors: intrahepatic cholangiocarcinoma (I-CCA), mixed tumors with hepatocellular carcinoma (HCC), and others, with overall survival rates of 71% at 1 year and 57% at 5 years post-transplant.
- Patients within Milan criteria, particularly those with I-CCA, exhibited promising survival rates, suggesting that LT could be a viable long-term option for certain patients.
Article Abstract
Background: The role of liver transplantation (LT) in the management of cirrhotic patients with tumors exhibiting intrahepatic bile duct differentiation remains controversial. The objective of this study was to characterize the spectrum of these tumors and analyze post-LT outcomes.
Methods: Retrospective pathology database search of explant histology analysis of liver transplants between April 1993 and November 2013.
Results: Thirty-two patients were analyzed, 75% were men with a mean age of 60 years. Seven patients had nodules demonstrating intrahepatic cholangiocarcinoma (I-CCA), nine had I-CCA nodules occurring concomitantly with hepatocellular carcinoma (HCC), and 16 had mixed HCC-CCA nodules. The median number of tumors was 1 and size was 2.5 cm. Overall patient survival post-LT at 1 and 5 years was 71% and 57%, respectively. Patients within Milan criteria, especially with I-CCA features, showed a 5-year tumor recurrence rate (10%) and 5-year survival rate (78%) comparable with other patients having HCC within Milan criteria.
Conclusion: This series showed that patients with CCA within Milan criteria may be able to achieve acceptable long-term post-LT survival.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/TP.0000000000000286 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!