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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119186 | PMC |
| http://dx.doi.org/10.1007/s10867-014-9359-7 | DOI Listing |
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Tertiary Lymphoid Structures as a Biomarker in Immunotherapy and Beyond: Advancing Towards Clinical Application.
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. Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. Electronic address:
Tertiary lymphoid structures (TLSs) are ectopic immune cell clusters formed in nonlymphoid tissues affected by persistent inflammation, such as in cancer and prolonged infections. They have features of the structure and function of secondary lymphoid organs, featuring central CD20+ B cells, surrounded by CD3+ T cells, CD21+ follicular dendritic cells, and CD68+ macrophages, with a complex vascular system. TLS formation is governed by lymphotoxin-α1β2, TNF, and chemokines like CCL19, CCL21, and CXCL13, differing from secondary lymphoid organ development in developing later in life at sites of chronic inflammation.
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An open chat between Prof Asifa Akhtar and Klaudia Jaczynska.
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To mark the International Day of Women and Girls in Science 2025, we invited Prof Asifa Akhtar, Vice President of the Max Planck Society's Biology and Medicine section, Director at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Honorary Professor at the Albert Ludwigs University and recipient of the 2025 FEBS | EMBO Women in Science Award to meet and chat with Klaudia Jaczynska, final year PhD student at Jose Rizo's laboratory in UT Southwestern Medical Center, Dallas, and 2024 FEBS Open Bio Article Prize winner. We invited them to talk about challenges limiting equal representation in science, technology, engineering and mathematics, initiatives to foster supportive environments as a research institute and the importance of highlighting diverse examples of success.
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