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Contact Lenses in Therapeutic Care: A Comprehensive Review of Past Innovations, Present Applications, and Future Directions.
Adv Exp Med Biol
January 2025
Department of Optometry, University of Benin, Benin City, Nigeria.
Contact lenses have become integral tools in the realm of ocular therapeutics, extending beyond their primary function of refractive correction to encompass a diverse array of therapeutic applications. This review explores the evolving role of contact lenses in managing various ocular conditions, highlighting their efficacy in enhancing patient outcomes. Initially developed to correct refractive errors, contact lenses now serve as effective vehicles for delivering medications directly to the ocular surface, offering targeted treatment for conditions such as dry eye syndrome and corneal ulcers.
View Article and Find Full Text PDFResearch focus and theme evolution on enhanced external counterpulsation: A bibliometric analysis.
Heliyon
January 2025
Department of Nursing, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Aims: The study delved into the identification of key research areas and evolving trends within the domain of Enhanced External Counterpulsation, aiming to gain comprehensive insights into the subject matter.
Methods: Utilizing the sophisticated search parameter of 'topic' (TS) on the Web of Science (WoS) database, the necessary information was retrieved. This research employed an array of tools for effective data extraction, analysis, and visualization, which included Microsoft Excel for tabular management, HistCite Pro for citation analysis, GunnMap for geographical mapping, BibExcel for bibliometric assessments, and VOSviewer for network visualization purposes.
Evolutionary patterns and research frontiers of artificial intelligence in age-related macular degeneration: a bibliometric analysis.
Quant Imaging Med Surg
January 2025
Department of Ophthalmology, Key Lab of Ocular Fundus Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background: Age-related macular degeneration (AMD) represents a significant clinical concern, particularly in aging populations, and recent advancements in artificial intelligence (AI) have catalyzed substantial research interest in this domain. Despite the growing body of literature, there remains a need for a comprehensive, quantitative analysis to delineate key trends and emerging areas in the field of AI applications in AMD. This bibliometric analysis sought to systematically evaluate the landscape of AI-focused research on AMD to illuminate publication patterns, influential contributors, and focal research trends.
View Article and Find Full Text PDFEngineering the Novel Extremophile Alga for High Lipid and High Starch Production as a Path to Developing Commercially Relevant Strains.
ACS ES T Eng
January 2025
Department of Molecular Biology, School of Biological Sciences, University of California San Diego, La Jolla, San Diego, California 92093, United States.
Microalgae offer a compelling platform for the production of commodity products, due to their superior photosynthetic efficiency, adaptability to nonarable lands and nonpotable water, and their capacity to produce a versatile array of bioproducts, including biofuels and biomaterials. However, the scalability of microalgae as a bioresource has been hindered by challenges such as costly biomass production related to vulnerability to pond crashes during large-scale cultivation. This study presents a pipeline for the genetic engineering and pilot-scale production of biodiesel and thermoplastic polyurethane precursors in the extremophile species .
View Article and Find Full Text PDFAromatic side-chain crosslinking in RiPP biosynthesis.
Nat Chem Biol
January 2025
Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.
Peptide cyclization is a defining feature of many bioactive molecules, particularly in the ribosomally synthesized and post-translationally modified peptide (RiPP) family of natural products. Although enzymes responsible for N- to C-terminal macrocyclization, lanthipeptide formation or heterocycle installation have been well documented, a diverse array of cyclases have been discovered that perform crosslinking of aromatic side chains. These enzymes form either biaryl linkages between two aromatic amino acids or a crosslink between one aliphatic amino acid and one aromatic amino acid.
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