The aim of our study was the use of different types of isolation systems in the treatment of experimentally simulated dental caries that will allow to present additional comparative characteristic for morphological responses of the pulp.For realization of this purpose, 3 systems have been selected: UltraBlend (Ultradent), Biodentine (Septodont) and adhesive system Prime&Bond NT (Dentsply). The study was conducted at the laboratory of Alexander Natishvili Institute of Morphology. For this experiment, 12 male, 6 months of age rabbits were selected. There were created 3 experimental groups, each of which included 4 rabbits. Restoration of the teeth in experimental rabbits with Biodentine revealed sufficient physical properties enabling the operator most comfortably conduct his/her clinical activities: kneading, bringing into caries cavity, condensing and filling dental defect. Isolation of dentin by Biodentine doesn't contradict and/or reduce application of adhesive systems, which is also important for teeth restorations. Biodentine has optimal working time (final curing 10-12 minutes) enabling the operator to conduct maximal formation of material at the bottom of caries cavity.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Immediate Pre-Endodontic Dentin Sealing (IPDS) Improves Resin-Dentin Bond Strength.
J Esthet Restor Dent
January 2025
Magne Education, Beverly Hills, California, USA.
Objective: Chemicals used during canal disinfection and endodontic sealers have a deleterious effect on dentin bond strength. The aim of this study was to evaluate a novel clinical sequence to improve the resin-dentin microtensile bond strength (μTBS) to endodontically treated teeth.
Materials And Methods: Twenty human molars were distributed in four experimental groups (n = 5, N = 20): C-control group without exposure to any endodontic chemical substances (2.
[Mitochondrial transfer contributes to the odontogenic differentiation of dental mesenchymal stem cells].
Zhonghua Kou Qiang Yi Xue Za Zhi
January 2025
Department of Implantology, Stomatological Hospital and Dental School, Tongji University & Shanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology, Shanghai200072, China.
Article Synopsis
- The study aimed to explore mitochondrial transfer in dental mesenchymal stem cells (MSCs) and its impact on their ability to differentiate into odontogenic cells.
- Flow cytometry, immunostaining, and advanced imaging techniques were utilized to analyze the presence and significance of mitochondrial transfer in these cells, revealing its role in promoting odontogenic differentiation.
- The research found evidence of mitochondrial transfer through structures called tunneling nanotubes (TNTs) and showed that inhibiting this transfer affected key differentiation markers and gene expression related to odontogenesis.
The Grotte du Bison Neandertals (Arcy-sur-Cure, France).
J Hum Evol
December 2024
Univ. Paris 1 Panthéon-Sorbonne, Univ. Paris Ouest Nanterre La Défense, MSH Mondes-CNRS-Ministère de la Culture, ArScAn, UMR 7041, 92000, Nanterre, France.
The Grotte du Bison, in Arcy-sur-Cure (Yonne, France), yielded a large assemblage of 49 Neandertal remains from late Mousterian layers, offering critical insights for the study of Middle to Upper Paleolithic populations of Western Europe. Previous studies described the external morphology of 13 isolated teeth and a partial maxilla. Building on this previous work, the current study provides further descriptions and analyses of the remains, including one postcranial fragment, six cranial fragments, two maxillary fragments, and 40 isolated teeth.
View Article and Find Full Text PDFLL-37 regulates odontogenic differentiation of dental pulp stem cells in an inflammatory microenvironment.
Stem Cell Res Ther
December 2024
Key Lab. of Oral Diseases Research, College and Hospital of Stomatology, Anhui Medical University, Hefei, 230032, Anhui Province, China.
Background: Inflammation often causes irreversible damage to dental pulp tissue. Dental pulp stem cells (DPSCs), which have multidirectional differentiation ability, play critical roles in the repair and regeneration of pulp tissue. However, the presence of proinflammatory factors can affect DPSCs proliferation, differentiation, migration, and other functions.
View Article and Find Full Text PDFGlutamine-αKG axis affects dentin regeneration and regulates osteo/odontogenic differentiation of mesenchymal adult stem cells via IGF2 m6A modification.
Stem Cell Res Ther
December 2024
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, Sichuan, China.
Background: Multi-lineage differentiation of mesenchymal adult stem cells (m-ASCs) is crucial for tissue regeneration and accompanied with metabolism reprogramming, among which dental-pulp-derived m-ASCs has obvious advantage of easy accessibility. Stem cell fate determination and differentiation are closely related to metabolism status in cell microenvironment, which could actively interact with epigenetic modification. In recent years, glutamine-α-ketoglutarate (αKG) axis was proved to be related to aging, tumorigenesis, osteogenesis etc.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!