The Lavalette function is generalized to a two-exponent function in order to represent data looking like a sigmoid on semilogarithmic plots. A Mandelbrot trick is suggested for further investigations, if more fit parameters are needed. The analyzed data is that of the number of adherents to the main religions in the 20th century.
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http://dx.doi.org/10.1103/PhysRevE.89.062803 | DOI Listing |
Sci Rep
February 2024
IFV, French Institute of Vine and Wine, IFV, INRAE, UMT Géno-Vigne, Institut Agro, 34398, Montpellier, France.
Quantifying healthy and degraded inner tissues in plants is of great interest in agronomy, for example, to assess plant health and quality and monitor physiological traits or diseases. However, detecting functional and degraded plant tissues in-vivo without harming the plant is extremely challenging. New solutions are needed in ligneous and perennial species, for which the sustainability of plantations is crucial.
View Article and Find Full Text PDFJ Neuroinflammation
February 2023
Sorbonne Université, INSERM, CNRS, UMR_S 968, Institut de la Vision, 17 rue Moreau, 75012, Paris, France.
Retinal melanosome/melanolipofuscin-containing cells (MCCs), clinically visible as hyperreflective foci (HRF) and a highly predictive imaging biomarker for the progression of age-related macular degeneration (AMD), are widely believed to be migrating retinal pigment epithelial (RPE) cells. Using human donor tissue, we identify the vast majority of MCCs as melanophages, melanosome/melanolipofuscin-laden mononuclear phagocytes (MPs). Using serial block-face scanning electron microscopy, RPE flatmounts, bone marrow transplantation and in vitro experiments, we show how retinal melanophages form by the transfer of melanosomes from the RPE to subretinal MPs when the "don't eat me" signal CD47 is blocked.
View Article and Find Full Text PDFCell
August 2021
Laboratory of Host-Pathogen Biology, The Rockefeller University, New York, NY 10065, USA. Electronic address:
Antibacterial agents target the products of essential genes but rarely achieve complete target inhibition. Thus, the all-or-none definition of essentiality afforded by traditional genetic approaches fails to discern the most attractive bacterial targets: those whose incomplete inhibition results in major fitness costs. In contrast, gene "vulnerability" is a continuous, quantifiable trait that relates the magnitude of gene inhibition to the effect on bacterial fitness.
View Article and Find Full Text PDFJ Altern Complement Med
July 2020
Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
As awareness of educator stress and burnout is at the forefront of issues faced in the education system, programs are being implemented to focus on the well-being and betterment of educators. Mindfulness is one such practice that has been found to increase wellness and, in many cases, decrease negative outcomes. In this study, the effects of a Mindfulness-Based Stress Reduction Program were measured in grade-school (K-12) educators.
View Article and Find Full Text PDFFront Immunol
November 2020
Institut de la Vision, Sorbonne Université, INSERM, CNRS, Paris, France.
CD36, a member of the class B scavenger receptor family, participates in Toll-like receptor signaling on mononuclear phagocytes (MP) and can promote sterile pathogenic inflammation. We here analyzed the effect of CD36 deficiency on retinal inflammation and photoreceptor degeneration, the hallmarks of age-related macular degeneration (AMD), that characterize mice. We analyzed subretinal MP accumulation, and cone- and rod-degeneration in light-challenged and aged, CD36 competent or deficient, hyper-inflammatory mice, using histology and immune-stained retinal flatmounts.
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