Chemotherapy is a common treatment for leukemia. Ruthenium complexes have shown potential utility in chemotherapy and photodynamic therapy. The identification of new chemotherapeutics agents is critical for further progress in the treatment of leukemia. Ruthenium complexes generally have lower toxicities compared to cisplatin attributed to their specific accumulation in cancer tissues. Based on these evidences, in the present work we studied the cytotoxic activity of the ruthenium(III) compound cis-tetraammine(oxalato)ruthenium(III) dithionate - {cis-[Ru(C2O4)(NH3)4]2(S2O6)} against human chronic myelogenous leukemia cells (K-562) tumor cell line. The tested compound induces cell death in a dose and time dependent manner on K-562 cells. It is found that the effect was improved linearly while prolonging the incubation time. Compared to the cell cycle profiles of untreated cells, flow cytometric analysis indicated the sub-G1 arresting effect of ruthenium compound on K-562 cells. In our study, {cis-[Ru(C2O4)(NH3)4]2(S2O6)} shows a significant increase in tailed cells in any of the concentrations tested compared with negative control. Consequently, the concentration of {cis-[Ru(C2O4)(NH3)4]2(S2O6)} might be associated cytotoxicity with direct effect on K-562 cells DNA. Thus, it can be deducted that ruthenium-based compounds present selectivity to enter both tumor and normal cells. Additional studies are needed to determine the molecular mechanisms of the active components and to evaluate the potential in vivo anticancer activity of the cis-tetraammine(oxalato)ruthenium(III) dithionate.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082535 | PMC |
| http://dx.doi.org/10.1186/2193-1801-3-301 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[C(NH)]SO: A SBBO-Like Dithionate Crystal with Large Optical Anisotropy.
Inorg Chem
December 2024
College of Chemistry and Materials Science, Hebei Research Center of the Basic Discipline of Synthetic Chemistry, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, Baoding 071002, China.
Investigating ultraviolet (UV) birefringent crystals is a focal point of research in recent years. The development of superior birefringent materials faces substantial challenges, primarily due to the need to pinpoint optimal fundamental building blocks and to perfect their geometric arrangement within the crystal lattice. By selecting a planar π-conjugated [C(NH)] group and a staggered [SO] group, we have successfully synthesized an organic-inorganic hybrid crystal, [C(NH)]SO.
View Article and Find Full Text PDFMechanism of synergistic removal of NO and SO by sodium bicarbonate.
RSC Adv
October 2023
College of Carbon Neutrality Future Technology, Sichuan University Chengdu 610065 China
Sodium bicarbonate (NaHCO) is considered to be an effective alkaline adsorbent for SO removal and surprisingly, the concentration of NO is significantly reduced along with the generation of NO during its desulfurization. Unfortunately, the mechanism of NO interaction with NaHCO, SO and O is ambiguous. In this work, the effects of absorption gas and absorber composition on SO/NO absorption performance were explored, the absorption products were characterized using XPS and SEM, and the Gibbs free energy of the inferred reaction path was calculated based on density functional theory (DFT).
View Article and Find Full Text PDFRare fatal poisoning through dermal exposure to paraquat.
SAGE Open Med Case Rep
December 2022
Department of Clinical Toxicology, School of Medicine, Isfahan Clinical Toxicology Research Center, Khorshid Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Paraquat skin contact occurs less frequently and is rarely fatal. This article reports a case of a 45-year-old man who presented with dysphagia, respiratory distress and grade two, and third skin burns focusing on the upper body after accidental exposure to paraquat. He was admitted to the hospital 6 days after the first contact.
View Article and Find Full Text PDFSodium dithionate (NaSO) induces oxidative damage in mice mitochondria heart tissue.
Toxicol Rep
June 2022
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Sodium dithionite (NaSO) is an inorganic sodium salt, a bleaching agent that has a reducing agent role and is generally used as food additive or preservative in the production of diverse foods and beverages. The aim of this study is to determine the effects of NaSO on cardiac mitochondria damage and biochemical parameters in male mice. NaSO were administered orally at doses of 10, 20, 50 and 100 mg/kg to male mice for 45 days.
View Article and Find Full Text PDFDesign and Synthesis of ()-5-(Substituted benzylidene)-3-cyclohexyl-2-thioxothiazolidin-4-one Analogues as Anti-Tyrosinase and Antioxidant Compounds: In Vitro and In Silico Insights.
Antioxidants (Basel)
September 2022
Department of Manufacturing Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea.
Many compounds containing the β-phenyl-α,β-unsaturated carbonyl (PUSC) scaffold, including cinnamamide derivatives, have been shown to inhibit tyrosinase potently in vitro and in vivo. Structural changes to cinnamamide derivatives were produced by adding a dithionate functional group to provide eight ()-5-(substituted benzylidene)-3-cyclohexyl-2-thioxothiazolidin-4-one analogs with high log values for skin. These analogs were synthesized using a two-step reaction, and their stereochemistry was confirmed using the values of C4 measured in proton-coupled C mode.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!