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Insulin blocks glutamate-induced neurotoxicity in differentiated SH-SY5Y neuronal cells. | LitMetric

Insulin blocks glutamate-induced neurotoxicity in differentiated SH-SY5Y neuronal cells.

Behav Neurol

Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, India.

Published: December 2014

AI Article Synopsis

Article Abstract

Insulin is a cytokine which promotes cell growth. Recently, a few published reports on insulin in different cell lines support the antiapoptotic effect of insulin. But the reports fail to explain the role of insulin in modulating glutamate-mediated neuronal cell death through excitotoxicity. Thus, we examined the neuroprotective effect of insulin on glutamate-induced toxicity on differentiated SH-SY5Y neuronal cells. Changes in cell viability were measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) based assay, while apoptotic damage was detected by acridine orange/ethidium bromide and Hoechst staining. Intracellular reactive oxygen species (ROS) accumulation and morphological alterations were also measured. Treatment with glutamate induced apoptosis, elevated ROS levels and caused damage to neurons. Insulin was able to attenuate the glutamate-induced excitotoxic damage to neuronal cells.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082871PMC
http://dx.doi.org/10.1155/2014/674164DOI Listing

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