[Outcome of patients with acute kidney injury in the course of neoplastic diseases].

Patients with malignancies are a group of increased risk of acute kidney injury (AKI). The aim of this study was to evaluate selected parameters characterizing acute kidney injury in patients with malignancies such as the cause ofAKI, previous kidney function, diuresis, duration of oligoanuria, the number of dialysis sessions, mortality and normalization of renal function in the course of AKI. We analyzed data of 387 patients with AKI (155 women, 232 men) aged 26-96 years treated in hospital wards of nephrological profile in the most requiring dialysis. Among the female the most frequent neoplasm were cervical cancer (26.4%), multiple myeloma (14.8%) and colorectal carcinoma (7.7%). In men the most common cancers localization was: the urinary bladder (25.4%), prostate (23.7%), colon (7.7%), and multiple myeloma (6.9%). In 14 patients 2 tumors were reported while in one 3 different cancers. In total, patients in the study group had 403 cancers, including 162 women and 241 men. Average serum creatinine was 752.1 micromol/l, and diuresis at the start of observation 483 ml/24h. Oligoanuria (less than 500 ml/24h) occurred in 64.9% of patients and lasted from 1 to 117 days, an average of 6.8 days. Because of severe AKI, most of patients (357-92.2%) were dialyzed, an average 4.6 of sessions. Mean hospital stay was 15.4 days. Some patients (20.1%) had impaired renal function, even before the AKI episode which indicate coexistence of chronic kidney disease in the study population. The most common cause of AKI was urine flow disorders seen in 53.2% of patients, especially ureteral obstruction. A numerous AKI episodes (26.1%) were caused by the loss of body fluids. In 21.2% of patients multifactorial causes of AKI were found. The mortality rate in the studied group was 33.9%.