Crashes occurring on rural two-lane highways are more likely to result in severe driver incapacitating injuries and fatalities. In this study, mixed logit models are developed to analyze driver injury severities in single-vehicle (SV) and multi-vehicle (MV) crashes on rural two-lane highways in New Mexico from 2010 to 2011. A series of significant contributing factors in terms of driver behavior, weather conditions, environmental characteristics, roadway geometric features and traffic compositions, are identified and their impacts on injury severities are quantified for these two types of crashes, respectively. Elasticity analyses and transferability tests were conducted to better understand the models' specification and generality. The research findings indicate that there are significant differences in causal attributes determining driver injury severities between SV and MV crashes. For example, more severe driver injuries and fatalities can be observed in MV crashes when motorcycles or trucks are involved. Dark lighting conditions and dusty weather conditions are found to significantly increase MV crash injury severities. However, SV crashes demonstrate different characteristics influencing driver injury severities. For example, the probability of having severe injury outcomes is higher when vans are identified in SV crashes. Drivers' overtaking actions will significantly increase SV crash injury severities. Although some common attributes, such as alcohol impaired driving, are significant in both SV and MV crash severity models, their effects on different injury outcomes vary substantially. This study provides a better understanding of similarities and differences in significant contributing factors and their impacts on driver injury severities between SV and MV crashes on rural two-lane highways. It is also helpful to develop cost-effective solutions or appropriate injury prevention strategies for rural SV and MV crashes.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.aap.2014.06.014 | DOI Listing |
Respir Res
January 2025
Department of Respiratory Intensive Care Unit, First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, P. R. China.
Background: Acute lung injury (ALI) is a severe condition with multifaceted causes, including inflammation and oxidative stress. This research investigates the influence of m6A (N6-methyladenosine) modification on GBP4, a protein pivotal for macrophage polarization, a critical immune response in ALI.
Methods: Utilizing a mouse model to induce ALI, the study analyzed GBP4 expression in alveolar macrophages.
BMC Genomics
January 2025
College of Forestry and Grassland, Nanjing Forestry University, Nanjing, 210037, China.
Cold stress in winter is one of the most severe abiotic stresses on plant growth and flourishing, and the selection of cold tolerant genotypes is an important strategy to ensure the safety of plant growth and development. Cyclocarya paliurus, a diclinous and versatile tree species originally in subtropical regions, has been introduced and cultivated in the warm temperate zone of China to meet the increasing market demand for its leaf yield. However, information regarding its cold tolerance remains limited.
View Article and Find Full Text PDFInflamm Res
January 2025
Department of Anesthesiology, Critical Care, and Surgery, Duke University School of Medicine, Durham, NC, USA.
Background: Mitochondria generate the adenosine triphosphate (ATP) necessary for eukaryotic cells, serving as their primary energy suppliers, and contribute to host defense by producing reactive oxygen species. In many critical illnesses, including sepsis, major trauma, and heatstroke, the vicious cycle between activated coagulation and inflammation results in tissue hypoxia-induced mitochondrial dysfunction, and impaired mitochondrial function contributes to thromboinflammation and cell death.
Methods: A computer-based online search was performed using the PubMed and Web of Science databases for published articles concerning sepsis, trauma, critical illnesses, cell death, mitochondria, inflammation, coagulopathy, and organ dysfunction.
Neurosurg Rev
January 2025
Department of Neurosurgery, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
To explore temporal dynamics of cerebral herniation through the calvarial defect after decompressive craniectomy. To investigate patterns of hemispheric asymmetry in ischemic stroke and traumatic brain injury after decompressive craniectomy.To assess clinical implications of hemispheric asymmetry evaluation in order to minimize cranioplasty complications.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
December 2024
Ligustilide, a phthalide compound extracted from Umbelliferae plants such as Angelica sinensis and Ligusticum chuanxiong, has been proven to possess various pharmacological activities, such as anti-inflammatory, anti-tumor, anti-atherosclerosis, anti-ischemic stroke injury, and anti-Alzheimer's disease properties. In recent years, it has shown great potential, particularly in the treatment of locomotor system diseases. Studies have shown that ligustilide has significant therapeutic effects on various locomotor system diseases, including osteoporosis, osteoarthritis, femoral head necrosis, osteosarcoma, and muscle aging and injury.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!