In this study, 100 HIV-positive cases (63 men, 37 women) with skin findings were included. The mean CD4 T cell count was 253 cells/mm(3). A total of 235 dermatological manifestations were seen. The common infectious dermatoses were candidiasis (21%), Staphylococcal skin infections (20%), dermatophytoses (14%) and herpes zoster (6%). Among the non-infectious dermatoses were papular pruritic eruptions (20%), xerosis/ichthyosis (20%) and seborrhoeic dermatitis (16%). Statistically significant association (p < 0.05) with CD4 T cell count was seen in pyodermas, dermatophytoses and papular pruritic eruptions. Adverse drug reactions, diffuse hair loss, straightening of hairs and pigmentary changes were also noted. Although there was an absence of Kaposi's sarcoma in our study, a case of verrucous carcinoma of penis was noted.

Download full-text PDF

Source
http://dx.doi.org/10.1177/0956462414543121DOI Listing

Publication Analysis

Top Keywords

spectrum mucocutaneous
4
mucocutaneous manifestations
4
manifestations human
4
human immunodeficiency
4
immunodeficiency virus-infected
4
virus-infected patients
4
patients correlation
4
correlation cd4
4
cd4 lymphocyte
4
lymphocyte count
4

Similar Publications

Exploring the binomial BALB/c-Leishmania (Viannia) braziliensis model to assess the in vivo performance of Thor strain subpopulations.

Exp Parasitol

December 2024

Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Biologia Molecular e Doenças Endêmicas, Rio de Janeiro, RJ, Brasil. Electronic address:

Article Synopsis
  • Leishmania (Viannia) braziliensis causes various types of leishmaniasis, and the study investigates how different subpopulations (Thor03, Thor10, Thor22) affect disease progression in BALB/c mice.
  • The research found that after three weeks of infection, Thor03 and Thor10 led to larger lesions and influenced immune response markers, showing lower IL-12 and TNF levels, while Thor10 had the highest IL-10 levels.
  • The study concluded that these subpopulations might lead to mild footpad lesions but can persist in lymph nodes, highlighting differences in infection patterns and immune responses among the subpopulations.
View Article and Find Full Text PDF

DOCK8 deficiency is the most common cause of autosomal recessive hyper-IgE syndrome (AR-HIES). The clinical spectrum is wide resulting in combined immunodeficiency, atopy, autoimmunity, and malignancies. To study the clinical and molecular profile of 20 patients with DOCK8 deficiency.

View Article and Find Full Text PDF

Background: Opportunistic fungal infections like oral candidiasis account for a significant amount of morbidity in HIV disease and an indicator of immune suppression. Fluconazole is a broad-spectrum antifungal agent that has been extensively used in the management of oral, candidiasis. Highly efficacious fluconazole is also known to have systemic toxicity due to high drug interaction and hence the present study focuses on the formulation of bioadhesive film as a controlled release carrier for fluconazole.

View Article and Find Full Text PDF

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe mucocutaneous reactions, often triggered by medications, characterized by blistering and epithelial sloughing. We report the case of a 66-year-old male who presented with a 2-day history of fluid-filled lesions on his body. On examination, erosions were observed on the posterior and anterior trunk, as well as on both upper and lower limbs.

View Article and Find Full Text PDF

Post-Stevens-Johnson Syndrome Bronchiolitis Obliterans: Report of a Complex Case and a Literature Review.

Cureus

November 2024

Respiratory Medicine, Dartford and Gravesham National Health Service (NHS) Trust, Dartford, GBR.

Bronchiolitis obliterans (BO) is a rare and severe respiratory complication of Stevens-Johnson syndrome (SJS), which primarily affects the small airways and causes progressive respiratory decline. We present the case of a young male with autism spectrum disorder who developed BO after an episode of SJS triggered by amoxicillin. Initially, the patient presented with an ulcerative rash and respiratory symptoms and received high-dose corticosteroids, leading to partial resolution of mucocutaneous lesions.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!