Persistent hyperkalaemia was found in a patient with vitamin B12 unresponsive methylmalonic acidaemia associated with hyperuricaemia. At 3 years and 8 months of age, a serum potassium level of 6.8 mmol L-1 was found when blood gas measurement was normal. One year later azotaemia was noted. At the age of 5 years, renal function studies disclosed hyperaldosteronism, decreased creatinine clearance, reduction of the reabsorption of sodium at distal diluting segments and inadequate concentration of urine at the collecting ducts. The reduction of the reabsorption of sodium, which may have resulted in decreased potassium excretion, and the decrease in glomerular filtration rate, together with the superimposed excess intake of potassium, appeared to be responsible for the hyperkalaemia. Dietary potassium restriction was effective in suppressing the hyperkalaemia.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF01805536 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hyperkalaemia during a general anaesthetic in a 5-year-old domestic short-haired cat.
Aust Vet J
January 2025
Western Australian Veterinary Emergency and Specialty, Success, Western Australia, Australia.
This case report details an incident of hyperkalaemia that developed under general anaesthesia in a domestic cat with no prior health concerns. A 5-year-old male neutered domestic short-haired cat presented for dental extractions and subsequently developed severe bradycardia and electrocardiographic abnormalities during the procedure. Initial treatment with atropine provided limited improvement, and further investigation revealed a serum potassium concentration of 7.
View Article and Find Full Text PDFCracking the code of aldosterone synthase deficiency: bridging genetics and biochemistry: a case report.
Lab Med
December 2024
Department of Pediatrics, AIIMS Patna, Patna, Bihar, India.
Objective: Aldosterone synthase deficiency (ASD) is a rare autosomal recessive inherited disease with an overall clinical phenotype of failure to thrive, vomiting, severe dehydration, hyperkalemia, and hyponatremia. Mutations in the CYP11B2 gene encoding AS are responsible for the occurrence of ASD. Defects in CYP11B2 gene have only been reported in a limited number of cases worldwide.
View Article and Find Full Text PDFA real-world pharmacovigilance analysis of adverse events associated with irbesartan using the FAERS and JADER databases.
Front Pharmacol
November 2024
Department of Cardiovascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Article Synopsis
- Hypertension is a major global health risk, and this study examined the safety of irbesartan, a medication used to treat it, by analyzing adverse drug events (ADEs) reported in the FDA's FAERS and Japan's JADER databases from 2004 to 2024.
- The research revealed significant positive signals for known and new ADEs, such as hyperkalemia and acute pancreatitis, indicating serious potential health risks associated with irbesartan use.
- Subgroup analyses showed variations in ADE occurrences based on age and gender, and further investigations confirmed key findings even when excluding other medications from the analysis.
Utilization of Potassium Binders for the Management of Hyperkalemia in Chronic Kidney Disease: A Position Statement by US Nephrologists.
Adv Kidney Dis Health
November 2024
Division of Nephrology, Department of Medicine, University of North Carolina Kidney Center, Chapel Hill, NC and the WG (Bill) Hefner Salisbury VA Medical Center, Salisbury, NC. Electronic address:
Two potassium (K) binders-patiromer sorbitex calcium and sodium zirconium cyclosilicate-are recommended by international guidelines for the management of hyperkalemia. There is, however, no universally accepted best practice for how to appropriately utilize K binders in the long-term clinical management of CKD. A panel of eight US-based nephrologists convened in October 2022 to develop a consensus statement regarding utilizing K binders in clinical practice to help manage patients with nonemergent, persistent/recurrent hyperkalemia in CKD.
View Article and Find Full Text PDFCombination of Diuretics in States of Resistant Nephrotic Edema: a Case Presentation.
Maedica (Bucur)
September 2024
Department of Nephrology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
While there remains no universally accepted definition for resistant edema, it is generally acknowledged as edema that fails to respond to maximally administered doses of diuretics. Nephrotic edema is characterized by high levels of proteinuria, notably urinary concentrations of serine proteases, which possess the ability to activate the epithelial sodium channel (ENaC), resulting in persistent fluid retention. Loop diuretics are typically preferred as first-line therapy for hypervolemia.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!