AI Article Synopsis
- Mononuclear phagocytes play a critical role in the initial immune response to acute viral infections by recognizing viral components and injury signals.
- Pattern recognition receptors (PRRs) like TLRs, RLRs, and NOD-like receptors are essential for triggering inflammatory responses and activating adaptive immunity.
- Different neurotropic viruses, such as HSV, West Nile virus, and HIV, utilize unique strategies to manipulate and evade the innate immune system, influencing infection severity and the effectiveness of vaccines.
Article Abstract
Innate immune responses mediated by mononuclear phagocytes represent the initial host response to acute viral infection. PRRs, including TLRs, retinoic RLRs,and NOD-like receptors, recognize viral nucleic acid and localized injury signals to initiate proinflammatory responses and activation of adaptive immunity. These responses are host- and viral-dependent. Neurotropic viruses, such as HSV, West Nile virus, and HIV activate and evade innate immune signaling mechanisms by distinct mechanisms. These highly complex pathogen-host interactions determine establishment of infection, severity of clinical disease, development of chronic inflammatory processes, and success of vaccination strategies.
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| http://dx.doi.org/10.1016/B978-0-444-53488-0.00009-2 | DOI Listing |
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