AI Article Synopsis
- * Researchers identified three distinct folded states of telomeric G4, which vary in how long they last and how stable they are under mechanical stress.
- * The findings reveal that the main way these G4 structures fold involves a brief intermediate state leading to a more stable form, and one ultra-stable form with significantly stronger mechanical properties was also discovered.
Article Abstract
As critical DNA structures capping the human chromosome ends, the stability and structural polymorphism of human telomeric G-quadruplex (G4) have drawn increasing attention in recent years. This work characterizes the equilibrium transitions of single-molecule telomeric G4 at physiological K(+) concentration. We report three folded states of telomeric G4 with markedly different lifetime and mechanical stability. Our results show that the kinetically favored folding pathway is through a short-lived intermediate state to a longer-lived state. By examining the force dependence of transition rates, the force-dependent transition free energy landscape for this pathway is determined. In addition, an ultra-long-lived form of telomeric G4 structure with a much stronger mechanical stability is identified.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117794 | PMC |
| http://dx.doi.org/10.1093/nar/gku581 | DOI Listing |
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