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Flipping a switch on BRD4: How to control the do-it-all.
Mol Cell
November 2024
Science for Life Laboratory, Stockholm, Sweden; Department of Gene Technology, KTH Royal Institute of Technology, Stockholm, Sweden. Electronic address:
In this issue, Devaiah et al. identify JNK-catalyzed phosphorylation to convert bromodomain-containing protein 4 (BRD4) from a chromatin regulator to a transcription activator.
View Article and Find Full Text PDFAllosteric mechanism of membrane fusion activation in a herpesvirus.
bioRxiv
September 2024
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 0211.
infect nearly all humans for life, causing diseases that range from painful to life-threatening. These viruses penetrate cells by employing a complex apparatus composed of separate receptor-binding, signal-transmitting, and membrane-fusing components. But how these components coordinate their functions is unknown.
View Article and Find Full Text PDFCrossing the membrane-What does it take to flip a phospholipid? Structural and biochemical advances on P4-ATPase flippases.
J Biol Chem
October 2024
Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Electronic address:
Membrane asymmetry is critical for maintenance of several different processes such as cell signaling, apoptosis, and vesicular transport in various eukaryotic systems. Flippases of the P4-ATPase family are associated with flipping phospholipids from the luminal or exoplasmic leaflet to the cytosolic leaflet. P4-ATPases belong to the P-type ATPase family, which are activated by phosphorylation and couple ATPase activity to substrate translocation.
View Article and Find Full Text PDF[Exploring a novel instructional paradigm for the Fundamentals of Immunity and Infection module in our university: A study based on the O-PIRTAS flipped classroom approach].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
August 2024
Department of Microbiology and Pathogen Biology, Basic Medical Science Academy, Air Force Medical University, Xi'an 710032, China. *Corresponding author, E-mail:
Medical Microbiology and Medical Immunology are important components of our university's the modular teaching on fundamentals of immunity and infection. Among these, Bacterial Infection and Immunity serves as a bridge between Medical Microbiology and Medical Immunology. This chapter mainly introduces how pathogenic bacteria invade the body to cause infection and how the body's immune system resists bacterial infection.
View Article and Find Full Text PDFComparative Study of the Flipped Classroom and Traditional Lecture Methods in Anatomy Teaching.
Cureus
July 2024
Department of Anatomy, All India Institute of Medical Sciences, Rishikesh, IND.
Background The National Medical Commission (NMC), the regulatory body for medical education in India introduced competency-based medical education (CBME) in 2019. It is an outcome-based learner-centric approach. To implement it, active and innovative learning strategies are being introduced.
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