AI Article Synopsis
- The study aims to develop a method for analyzing effective components in traditional Chinese medicines, using Carthamus tinctorius (safflower) as a case study.
- Researchers depleted the major components of safflower and assessed their antioxidant effects to identify which materials contributed most significantly to its efficacy.
- Findings revealed that three specific compounds (hydroxysafflor yellow A, anhydrosafflor yellow B, and 6-hydroxykaempferol-3, 6-di-O-glucoside-7-O-glucuronide) were key efficacious materials, indicating the effectiveness of the proposed study method.
Article Abstract
Objective: To establish a method for studying efficacious materials of traditional Chinese medicines from an overall perspective.
Method: Carthamus tinctorius was taken the example. Its major components were depleted by preparing liquid chromatography. Afterwards, the samples with major components depleted were evaluated for their antioxidant effect, so as to compare and analyze the major efficacious materials of C. tinctorius with antioxidant activity and the contributions.
Result: Seven major components were depleted from C. tinctorius samples, and six of them were identified with MS data and control comparison. After all of the samples including depleted materials are compared and evaluated for their antioxidant effect, the findings showed that hydroxysafflor yellow A, anhydrosafflor yellow B and 6-hydroxykaempferol-3, 6-di-O-glucoside-7-O-glucuronide were the major efficacious materials.
Conclusion: This study explored a novel and effective method for studying efficacious materials of traditional Chinese medicines. Through this method, we could explain the direct and indirect contributions of different components to the efficacy of traditional Chinese medicines, and make the efficacious material expression of traditional Chinese medicines clearer.
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