AI Article Synopsis
- Adhesion to host cells is essential for pathogen colonization and helps microbes evade the immune response, while also provoking that immune response to defend against infections.
- Adhesins are key surface molecules on microbes that facilitate their attachment to host cells and are crucial for biofilm formation and bacterial aggregation.
- The review focuses on the role of adhesins in Mycobacterium tuberculosis pathogenesis, explores their structure and characteristics, and discusses their potential as targets for new tuberculosis control strategies.
Article Abstract
Adhesion to host cells is a precursor to host colonization and evasion of the host immune response. Conversely, it triggers the induction of the immune response, a process vital to the host's defence against infection. Adhesins are microbial cell surface molecules or structures that mediate the attachment of the microbe to host cells and thus the host-pathogen interaction. They also play a crucial role in bacterial aggregation and biofilm formation. In this review, we discuss the role of adhesins in the pathogenesis of the aetiological agent of tuberculosis, Mycobacterium tuberculosis. We also provide insight into the structure and characteristics of some of the characterized and putative M. tuberculosis adhesins. Finally, we examine the potential of adhesins as targets for the development of tuberculosis control strategies.
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| http://dx.doi.org/10.1099/mic.0.082206-0 | DOI Listing |
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