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Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in Colombian patients with AIDS for diagnosis and follow-up during therapy. | LitMetric
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Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in Colombian patients with AIDS for diagnosis and follow-up during therapy.

Diego H Caceres Christina M Scheel Angela M Tobón Angela Ahlquist Cleveland Angela Restrepo Mary E Brandt Tom Chiller Beatriz L Gómez

Clin Vaccine Immunol

Corporación para Investigaciones Biológicas (CIB), Medical and Experimental Mycology Group, Medellín, Colombia Universidad del Rosario, School of Medicine and Health Sciences, BogotÁ, Colombia

Published: September 2014

We validated an antigen capture enzyme-linked immunosorbent assay (ELISA) in Colombian persons with AIDS and proven histoplasmosis and evaluated the correlation between antigenuria and clinical improvement during follow-up. The sensitivity of the Histoplasma capsulatum ELISA was 86%, and the overall specificity was 94%. The antigen test successfully monitored the response to therapy.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178582PMC
http://dx.doi.org/10.1128/CVI.00101-14DOI Listing

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