AI Article Synopsis
- - This study explores how insulin issues might link diabetes and Alzheimer's disease (AD) by using a high-fat diet in a mouse model with AD-like conditions.
- - Researchers found that a human AD gene led to glucose intolerance and pancreatic Aβ buildup, which worsened with high-fat diets, causing further memory problems.
- - Interestingly, a single insulin injection was able to reverse some negative effects on memory and Aβ levels, suggesting that insulin could offer new therapeutic options for combating the relationship between AD and diabetes.
Article Abstract
Defects in insulin production and signaling are suspected to share a key role in diabetes and Alzheimer disease (AD), two age-related pathologies. In this study, we investigated the interrelation between AD and diabetes using a high-fat diet (HFD) in a mouse model of genetically induced AD-like neuropathology (3xTg-AD). We first observed that cerebral expression of human AD transgenes led to peripheral glucose intolerance, associated with pancreatic human Aβ accumulation. High-fat diet enhanced glucose intolerance, brain soluble Aβ, and memory impairment in 3xTg-AD mice. Strikingly, a single insulin injection reversed the deleterious effects of HFD on memory and soluble Aβ levels, partly through changes in Aβ production and/or clearance. Our results are consistent with the development of a vicious cycle between AD and diabetes, potentiating both peripheral metabolic disorders and AD neuropathology. The capacity of insulin to rapidly break the deleterious effects of this cycle on soluble Aβ concentrations and memory has important therapeutic implications.
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| http://dx.doi.org/10.2337/db14-0375 | DOI Listing |
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