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Weekly Journal Scan: A CLEAR message questions the routine use of spironolactone in acute myocardial infarction.
Eur Heart J
January 2025
Department of Clinical and Molecular Medicine, Sapienza University of Rome, Via di Grottarossa1035, Rome, Italy.
Outcomes after medical treatment for primary aldosteronism: an international consensus and analysis of treatment response in an international cohort.
Lancet Diabetes Endocrinol
January 2025
Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, VIC, Australia; Department of Endocrinology, Monash Health, Clayton, VIC, Australia.
Background: Primary aldosteronism can be treated medically but there is no standardised method to evaluate treatment outcomes. We aimed to develop criteria for assessing the outcomes of targeted medical treatment of primary aldosteronism, analyse outcomes across an international cohort, and identify factors associated with a complete treatment response.
Methods: An international panel of 31 primary aldosteronism experts used the Delphi method to reach consensus on the definition of complete, partial, or absent biochemical and clinical outcomes of medical treatment of primary aldosteronism.
The impact of combination of zofenopril and different diuretics on regression of myocardial reperfusion injury and oxidative status in spontaneously hypertensive rats.
Mol Cell Biochem
January 2025
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 34000, Kragujevac, Serbia.
Article Synopsis
- The study investigated the effects of ACE inhibitors and diuretics on heart damage from ischemia-reperfusion in hypertensive rats, showing significant blood pressure reduction and improved heart function.
- After four weeks of treatment, a combination of drugs decreased left ventricular hypertrophy and increased ejection fraction, but also indicated potential pro-oxidative effects.
- Pathological analysis revealed no significant changes in heart and kidney tissues, and further research is necessary to explore the long-term effects of these medications.
[Optimization of heart failure treatment in Abidjan heart institute].
Ann Cardiol Angeiol (Paris)
February 2025
Institut de cardiologie d'Abidjan, Côte d'Ivoire.
Introduction: The aim of the study was to assess the level of treatment optimization after follow-up at discharge.
Methods: We conducted a retrospective study carried out from January 1st, 2016 to December 31st, 2018 in Abidjan Heart Institute with patients hospitalized for heart failure and reviewed in consultation.
Results: The study involved 350 patients with an average age of 53.
Prevalence and correlates of uncontrolled hypertension and cardiovascular morbidity among patients with hypertension at the largest tertiary care hospital in Sri Lanka.
J Hypertens
December 2024
University/British Heart Foundation Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, Scotland, UK.
Introduction: Hypertension is the leading preventable cause of cardiovascular morbidity and mortality globally, with a disproportionate impact on low-income and middle-income countries like Sri Lanka. Effective blood pressure (BP) control improves outcomes in patients with hypertension. This study aimed to assess the prevalence of uncontrolled hypertension, and its correlates among Sri Lankan patients with hypertension in clinic settings.
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