AI Article Synopsis
- The study examined the importance of circulating tumor cells (CTCs) in predicting outcomes for nonmetastatic rectal cancer patients who received short-term preoperative radiotherapy.
- Out of 162 patients, 91 underwent molecular analysis to evaluate CTC clearance using specific genetic markers, revealing that CTC presence 7 days post-surgery linked significantly to local recurrence.
- Preoperative CTC detection showed no significant prognostic value, but a significant clearance was noted 24 hours after surgery, highlighting its role in assessing lymph node status and local recurrence risk.
Article Abstract
The aim of this study was to evaluate the prognostic value of circulating tumor cells (CTC) in nonmetastatic rectal cancer patients treated with short-term preoperative radiotherapy. In this single-center trial, 162 patients with rectal cancer after preoperative short-term radiotherapy (5 × 5 Gy) were recruited from January, 2008 to September, 2011. Clearance of CTC was determined in 91 patients enrolled in the molecular analysis. CTC presence was evaluated with real-time reverse transcription polymerase chain reaction assay (qPCR) based on the expression of three tumor genetic markers: carcinoembryonic antigen (CEA), cytokeratin 20 (CK20), and/or cancer stem cells marker CD133 (CEA/CK20/CD133). We found that CTC detection 7 days after surgery was of prognostic significance for the local recurrence (P value = 0.006). CTC detected preoperatively and 24 hours after resection had no prognostic value in cancer recurrence; however, there was a significant relationship between CTC prevalence 24 hours after surgery and lymph node metastasis (pN1-2). We also confirmed a significant clearance of CTC in peripheral blood (PB) 24 hours after surgery. Preoperative sampling is not significant for prognosis in rectal cancer patients treated with short-term radiotherapy. Detection of CTC in PB 7 days after surgery is an independent factor predicting local recurrence in this group of patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070579 | PMC |
| http://dx.doi.org/10.1155/2014/712827 | DOI Listing |
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