Most computer algorithms used clinically for photon beam treatment planning are unable to predict the effect of electron backscattering on dose distribution from high atomic number materials. It has been observed that there is a significant dose enhancement at such an interface. We define the dose enhancement in terms of backscatter dose factor (BSDF), which depends on the energy of the photon beam, thickness and width of the inhomogeneity, distance from the interface, and the atomic number of the inhomogeneity. For all energies studied, the dose fall-off is initially very rapid and disappears beyond a few millimeters upstream from the interface. Empirically derived equations are presented for dose calculation at the interfaces of various media, including bone and soft tissue, for photon energies in the range of Co-60 gamma rays to 24 MV x rays.
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http://dx.doi.org/10.1118/1.596345 | DOI Listing |
Talanta
January 2025
National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Chiba, Chiba, 263-8555, Japan; Department of Physics, Faculty of Science, Toho University, 2-2-1 Miyama, Funabashi, Chiba, 274-8510, Japan.
Natural uranium isotopes have extremely long half-lives; therefore, analytical methods based on the number of atoms, such as X-ray fluorescence (XRF) analysis, are suitable for uranium detection. However, XRF measurements cannot be used to detect the major isotopes of americium when present in amounts barely detectable using radiation measurements, owing to their relatively short half-lives. Because of α-decay-induced internal conversion, where orbital electrons are emitted instead of γ-rays, these nuclides emit characteristic X-rays.
View Article and Find Full Text PDFNative ion channels play key roles in biological systems, and engineered versions are widely used as chemogenetic tools and in sensing devices . Protein design has been harnessed to generate pore-containing transmembrane proteins, but the capability to design ion selectivity based on the interactions between ions and selectivity filter residues, a crucial feature of native ion channels , has been constrained by the lack of methods to place the metal-coordinating residues with atomic-level precision. Here we describe a bottom-up RFdiffusion-based approach to construct Ca channels from defined selectivity filter residue geometries, and use this approach to design symmetric oligomeric channels with Ca selectivity filters having different coordination numbers and different geometries at the entrance of a wide pore buttressed by multiple transmembrane helices.
View Article and Find Full Text PDFJ Phys Condens Matter
January 2025
Institute of Nano Science and Technology, Sector 81, Knowledge City, Manauli, Mohali, Mohali, Punjab, 140306, INDIA.
Two-dimensional (2D) materials hold great promise for the next-generation optoelectronics applications, many of which, including solar cell, rely on the efficient dissociation of exciton into free charge carriers. However, photoexcitation in atomically thin 2D semiconductors typically produces exciton with a binding energy of ~500 meV, an order of magnitude larger than thermal energy at room temperature. This inefficient exciton dissociation can limit the efficiency of photovoltaics.
View Article and Find Full Text PDFRep Pract Oncol Radiother
December 2024
Radiobiology Laboratory, Department of Molecular Biology and Biotechnology, Atomic Energy Commission (AEC), Damascus, Syria.
Background: Angiogenesis is mediated by endothelial progenitor cells (EPCs) derived from bone-marrow. In this prospective study, we tried to investigate the clinical utility of circulating EPCs in lung cancer (LC) patients.
Materials And Methods: Flow cytometry technique was used to assess circulating EPCs according to the immuno-phenotype CD45 CD34 CD133 CD146 mononuclear cells.
ACS Omega
December 2024
Division of Solid-State Electronics, Department of Electrical Engineering, The Ångström Laboratory, Uppsala University, SE-751 03 Uppsala, Sweden.
Extracellular vesicles (EVs) are nanoparticles encapsulated with a lipid bilayer, and they constitute an excellent source of biomarkers for multiple diseases. However, the heterogeneity in their molecular compositions constitutes a major challenge for their recognition and profiling, thereby limiting their application as an effective biomarker. A single-EV analysis technique is crucial to both the discovery and the detection of EV subpopulations that carry disease-specific signatures.
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