AI Article Synopsis
- The study indicates that Zambian individuals with HIV-1 superinfection show low binding and neutralizing antibody responses to their initial HIV-1 strain, potentially making them more vulnerable to re-infection.
- Researchers found that these superinfected individuals also have reduced antibody-dependent cellular cytotoxicity (ADCC) activity, which is essential for killing virus-infected cells, when compared to non-superinfected individuals.
- Despite the low ADCC activity, superinfected individuals maintain similar levels of antibodies that react to CMV, indicating they can still develop and keep virus-specific antibodies.
Article Abstract
We have previously shown that HIV-1 superinfected Zambian seroconverters mount low binding and neutralizing antibody responses to their primary HIV-1 infecting virus, which could increase susceptibility to re-infection. Here, we investigated if antibody-dependent cellular cytotoxicity (ADCC), a process by which virus-infected cells are killed, was also reduced. Superinfected individuals exhibited low ADCC activity compared to non-superinfected individuals, but similar levels of CMV-reactive binding antibodies, suggesting superinfected individuals are capable of generating and maintaining virus-specific antibodies.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125417 | PMC |
| http://dx.doi.org/10.1016/j.virol.2014.06.016 | DOI Listing |
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