In the present study, we aimed to investigate the preventive effects of 4-hydroxychalcone (4HCH) on resistant hypertension. We used cryptochrome-null mice, which characteristically show high plasma aldosterone levels, inflammation, and renal injury. The cryptochrome-null mice received high-salt treatment and were treated orally with 4HCH 10 mg/kg, 4HCH 20 mg/kg, and 4HCH 40 mg/kg, respectively. The salt administration in cryptochrome-null mice is able to induce an increase in systolic pressure which is associated with hyperaldosteronism, inflammation, and kidney injury. Treatment with 40 mg/kg 4HCH reduced systolic hypertension, serum IL-1β, and TNF-α levels and suppressed the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and renal injury. The impact of 4HCH on the hyperaldosteronism, inflammation, and kidney injury provides new insights for future development of therapeutic strategies in resistant hypertension.
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| http://dx.doi.org/10.1155/2014/603415 | DOI Listing |
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Article Synopsis
- Aldosterone plays a critical role in regulating electrolyte and fluid balance but can also negatively impact kidney health.
- Previous studies on aldosterone's harmful effects often involved injury models, making it hard to isolate its impact from confounding factors like salt and hypertension.
- Our research using cryptochrome-null mice with naturally high aldosterone levels revealed kidney damage even without high salt or hypertension, indicating that aldosterone's detrimental effects can occur independently.
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