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Human liver cell-based assays for the prediction of hepatic bile acid efflux transporter inhibition by drugs.
Expert Opin Drug Metab Toxicol
January 2025
Institut de R&D Servier, Paris-Saclay, F-91190 Gif-sur-Yvette, France.
Introduction: Drug-mediated inhibition of bile salt efflux transporters may cause liver injury. In vitro prediction of drug effects toward canalicular and/or sinusoidal efflux of bile salts from human hepatocytes is therefore a major issue, which can be addressed using liver cell-based assays.
Area Covered: This review, based on a thorough literature search in the scientific databases PubMed and Web of Science, provides key information about hepatic transporters implicated in bile salt efflux, the human liver cell models available for investigating functional inhibition of bile salt efflux, the different methodologies used for this purpose, and the modes of expression of the results.
Comparison of the safety and efficacy of ciprofol monotherapy versus combined propofol for painless gastroscopy.
Pak J Pharm Sci
January 2025
Department of Anesthesiology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Jiangsu, China.
Traditional sedatives like Propofol can lead to adverse effects. This study compares the safety and efficacy of Ciprofol monotherapy versus combined Propofol for painless gastroscopy. Patients underwent painless gastroscopy at our hospital from January 2023 to December 2023 were studied.
View Article and Find Full Text PDFEthnobotany of vascular plants use, conservation and management practice in the homegardens by the people of Dawuro in Southwestern Ethiopia.
J Ethnobiol Ethnomed
January 2025
Department of Biology, College of Natural and Computational Science, Arba Minch University, Arba Minch, Ethiopia.
Background: Homegardens (HGs) are well-time-honored traditional land use systems in small plots of land with purposely designed intricate structure and a mixture of planted vascular plants (VPs) for different purposes. Hence, the present study was initiated to investigate the ethnobotanical information of vascular plants of homegardens and their use, conservation and management practice by the people of Dawuro in southwestern Ethiopia.
Methods: A total of 162 farmer informants were selected and interviewed within a distance of < 2 km, 2-4 km and > 4 km between the natural forest and homegardens, and 0.
Dropping out of a peripartum depression mHealth study: participants' motives and suggestions for improvement.
BMC Med Res Methodol
January 2025
Department of Women's and Children's Health - Obstetric & Reproductive Health Research, Uppsala University, Uppsala, 751 85, Sweden.
Background: Peripartum depression is a common but potentially debilitating pregnancy complication. Mobile applications can be used to collect data throughout the pregnancy and postpartum period to improve understanding of early risk indicators.
Aim: This study aimed to improve understanding of why women drop out of a peripartum depression mHealth study, and how we can improve the app design.
Beliefs and perceptions towards congenital anomalies in Dilla town, Gedeo Zone, Southern Ethiopia; a qualitative study.
BMC Pediatr
January 2025
School of Public Health, College Of Health Sciences and Medicine, Dilla University, Dilla, Ethiopia.
Introduction: Morbidity and mortality associated with congenital anomalies are higher in low-income countries. People's knowledge, beliefs, and attitudes towards congenital anomalies vary from community to community. In some communities, it is believed to be untreatable and the burden remains devastating.
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