AI Article Synopsis
- - Host susceptibility to environmental factors is a key reason for asthma development, and new genomic technologies are helping us understand this better.
- - Research has led to the identification of new biomarkers and transcriptomic phenotypes that improve asthma classification and help in the development of targeted treatments.
- - Despite the valuable insights gained from transcriptomic studies, there is still untapped potential for these findings to enhance diagnosis and treatment in clinical practice for asthma patients.
Article Abstract
Host susceptibility to environmental triggers is the most likely explanation for the development of asthma. Quantifying gene expression levels in disease-relevant tissues and cell types using fast evolving genomic technologies have generated new hypotheses about the pathogenesis of asthma and identified new therapeutic targets to treat asthma and asthma-exacerbations. New biomarkers and distinct transcriptomic phenotypes in blood, sputum and other tissues were also identified and proved effective to refine asthma classification and guide targeted therapies. The wealth of information provided by transcriptomic studies in asthma is yet to be fully exploited, but discoveries in this field may soon be implemented in clinical settings to improve diagnosis and treatment of patients afflicted with this common disease.
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| http://dx.doi.org/10.1586/1744666X.2014.932249 | DOI Listing |
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