Antifungal drugs have been proposed as a novel treatment for Acanthamoeba keratitis. The cysticidal activity of several antifungal compounds was tested against different genotypes of culture collection and clinical isolates of Acanthamoeba. Only voriconazole and posaconazole were found to be cysticidal, with no differences in activity observed between clinical and culture collection isolates.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135811 | PMC |
| http://dx.doi.org/10.1128/AAC.02635-14 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of Cinnamaldehyde and Its Nanoemulsion on Acanthamoeba castellanii Cysts and Trophozoites.
Acta Parasitol
January 2025
Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Purpose: The current study aimed to investigate the trophocidal and cysticidal activities of cinnamaldehyde (Cinn), a natural compound with known antimicrobial properties, against environmental and reference strains of Acanthamoeba castellanii. Additionally, we explored the potential benefits of Cinn formulated as a nanoemulsion (Cinn-NE) in enhancing its efficacy.
Methods: Cinn-NE was prepared using the ultrasonic emulsification method.
Amoebicidal and cysticidal in vitro activity of cationic dendritic molecules against Acanthamoeba polyphaga and Acanthamoeba griffini.
Parasitol Res
November 2024
University of Alcala, Department of Biomedicine and Biotechnology, 28805, Madrid, Spain.
Acanthamoeba species are responsible for serious human infections, including Acanthamoeba keratitis (AK) and granulomatous amoebic encephalitis (GAE). These pathogens have a simple life cycle consisting of an infective trophozoite stage and a resistant cyst stage, with cysts posing significant treatment challenges due to their resilience against harsh conditions and chemical agents. Current treatments for AK often involve combining diamines, such as propamidine, and biguanides, such as chlorhexidine (CLX), which exhibit limited efficacy and significant toxicity.
View Article and Find Full Text PDFPlants of the family Lamiaceae as a source of therapeutic agents against Acanthamoeba infections.
Mem Inst Oswaldo Cruz
November 2024
Comenius University in Bratislava, Faculty of Natural Sciences, Department of Zoology, Bratislava, Slovakia.
Background: Acanthamoebae are causative agents of severe and complicated human infections without a standard effective therapy to date. Therefore, the research is focused on the development of new amoebicidal drugs based on the natural products. Plants of the family Lamiaceae are typical with several phenolic secondary metabolites that make them interesting in medical point of view.
View Article and Find Full Text PDFThe in vitro effect riboflavin combined with or without UVA in Acanthamoeba castellanii.
Sci Rep
November 2024
Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.
The anti-Acanthamoeba properties of riboflavin and its enhanced amoebicidal effects when combined with ultraviolet A (UVA) radiation were investigated in vitro. The viability of cultured Acanthamoeba castellanii was assessed by adding varying concentrations (0 ~ 0.2% w/v) of riboflavin to the culture medium or after combined riboflavin and UVA treatment (30 min, 3 mW/cm) over 1, 3, 5, and 7 days.
View Article and Find Full Text PDFEVALUATION OF THE CYSTICIDAL ACTIVITY OF CHLOROCRESOL AGAINST ACANTHAMOEBA POLYPHAGA.
J Parasitol
October 2024
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen Province, Mitraparp Road, Thailand 40002.
Chlorocresol has antibacterial and antifungal properties, yet its effectiveness in eradicating Acanthamoeba spp. remains unexplored. Acanthamoeba species trophozoites are usually sensitive to biocides, whereas cysts tend to be more resistant.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!