AI Article Synopsis
- A study aimed to identify factors that predict the long-term success of treatments to eliminate Pseudomonas aeruginosa in cystic fibrosis (CF) patients.
- Researchers analyzed data from CF patients treated between 2005 and 2008, focusing on antibody responses one year post-treatment and their correlation with successful eradication three years later.
- The results showed that specific antibodies could predict treatment outcomes, with a 75% positive and 82% negative predictive value for long-term success, as 60% of patients achieved successful eradication.
Article Abstract
Background: Patient dependent parameters to predict the long-term success of early eradication treatment of Pseudomonas aeruginosa have not yet been defined. For this purpose we assessed serum antibodies against P. aeruginosa in CF patients after early eradication treatment.
Methods: Retrospective analyses of all consecutive patients with first P. aeruginosa detection 2005 to 2008. Absence of P. aeruginosa in the third year was defined as successful long-term eradication. Main outcome was to determine the predictive value of P. aeruginosa antibody results one year after initiation of early eradication treatment using antibodies against alkaline protease, elastase, and exotoxin A with regard to long-term success of eradication treatment.
Results: Antibodies against P. aeruginosa correlated well with success of eradication; positive and negative predictive values after one year were 75% and 82% respectively. The incidence of new detection of P. aeruginosa was 8.5%. Long-term eradication was successful in 32 of 53 patients (60%).
Conclusions: Determination of serum antibodies against P. aeruginosa one year after first detection of P. aeruginosa and early eradication treatment can predict success of long-term eradication.
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| http://dx.doi.org/10.1016/j.jcf.2014.06.006 | DOI Listing |
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