An effective method for aminoacylation of indoles and pyrroles has been achieved. The transformation involves a multicomponent one-pot cascade reaction between indoles or pyrroles, ynol ethers, and sulfonyl azides, creating four different bonds regioselectively through N-sulfonyltriazole intermediates. The oxo-tryptamines and oxo-pyrroloethanamines are generated in moderate to high yields under mild reaction conditions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ja5058967 | DOI Listing |
Publication Analysis
Top Keywords
indoles pyrroles
12
aminoacylation indoles
8
ynol ethers
8
ethers sulfonyl
8
sulfonyl azides
8
mild aminoacylation
4
pyrroles three-component
4
three-component reaction
4
reaction ynol
4
azides effective
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!