Noncontact robotic particle grippers with trapping, manipulation, and release functions are highly desired in cell biology and microfluidics. Optoelectric techniques combine optical and electrokinetic effects to create thousands of such individually addressable traps. By projecting reconfigurable light patterns, these techniques can concentrate molecules, as well as manipulate, sort, and electroporate cells in a programmable manner. We describe the underlying physical mechanisms and discuss applications in biology and future prospects of these devices.
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http://dx.doi.org/10.1016/j.tibtech.2014.06.002 | DOI Listing |
Lab Chip
January 2024
Industrialization Center of Micro/Nano ICs and Devices, Sino-German College of Intelligent Manufacturing, Shenzhen Technology University, Shenzhen 518118, China.
This work reports the development of a novel microfluidic biosensor using a graphene field-effect transistor (GFET) design for the parallel label-free analysis of multiple biomarkers. Overcoming the persistent challenge of constructing μm-sized FET sensitive interfaces that incorporate multiple receptors, we implement a split-float-gate structure that enables the manipulation of multiplexed biochemical functionalization using microfluidic channels. Immunoaffinity biosensing experiments are conducted using the mixture samples containing three liver cancer biomarkers, carcinoembryonic antigen (CEA), α-fetoprotein (AFP), and parathyroid hormone (PTH).
View Article and Find Full Text PDFMultifunctional optical fiber-based neural interfaces have attracted significant attention for neural stimulation, recording, and photopharmacology towards understanding the central nervous system. In this work, we demonstrate the fabrication, optoelectrical characterization, and mechanical analysis of four types of microstructured polymer optical fiber neural probes using different soft thermoplastic polymers. The developed devices have integrated metallic elements for electrophysiology and microfluidic channels for localized drug delivery, and can be used for optogenetics in the visible spectrum at wavelengths spanning from 450 nm up to 800 nm.
View Article and Find Full Text PDFNanoscale
September 2021
McGill University, Department of Bioengineering, Montreal, QC H3A 0E9, Canada.
Non-invasive liquid biopsies offer hope for a rapid, risk-free, real-time glimpse into cancer diagnostics. Recently, hydrogen peroxide (HO) was identified as a cancer biomarker due to its continued release from cancer cells compared to normal cells. The precise monitoring and quantification of HO are hindered by its low concentration and the limit of detection (LOD) in traditional sensing methods.
View Article and Find Full Text PDFLab Chip
June 2017
State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Science, Shenyang, 10016, China.
Trapping and transporting microorganisms with intrinsic motility are important tasks for biological, physical, and biomedical applications. However, fast swimming speed makes the manipulation of these organisms an inherently challenging task. In this study, we demonstrated that an optoelectrical technique, namely, optically induced dielectrophoresis (ODEP), could effectively trap and manipulate Chlamydomonas reinhardtii (C.
View Article and Find Full Text PDFLab Chip
March 2016
Department of Mechanical Engineering and Birck Nanotechnology Center, Purdue University, West Lafayette, 47907, USA.
Non-contact manipulation methods capable of trapping and transporting swimming bacteria can significantly aid in chemotaxis studies. However, high swimming speed makes the trapping of these organisms an inherently challenging task. We demonstrate that an optoelectric technique, rapid electrokinetic patterning (REP), can effectively trap and manipulate Enterobacter aerogenes bacteria swimming at velocities greater than 20 μm s(-1).
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!