AI Article Synopsis
- The study aimed to determine the prevalence of sessile serrated adenomas and polyps (SSA/Ps) among patients undergoing colonoscopy, utilizing a skilled colonoscopist and an expert pathologist.
- A total of 1910 asymptomatic, average-risk patients aged 50 and above were assessed, with findings showing that 8.1% were identified as having SSA/Ps, including 0.6% with cytologic dysplasia.
- The results suggest that SSA/Ps are more prevalent than previously thought, challenging earlier assumptions about their occurrence in the screening population.
Article Abstract
Background: The prevalence of sessile serrated adenomas and/or polyps (SSA/Ps) is uncertain.
Objective: To determine the prevalence of SSA/Ps and SSA/Ps with cytologic dysplasia (SSA/P-CD) by using a colonoscopist with a high lesion detection rate and an expert in serrated lesion pathology.
Design: Retrospective screening colonoscopy study.
Setting: Academic endoscopy unit.
Patients: A total of 1910 average risk, asymptomatic patients aged ≥50 years underwent screening colonoscopy between August 2005 and April 2012 by a single colonoscopist with a high lesion detection rate.
Interventions: Slides of all lesions in the serrated class proximal to the sigmoid colon and all rectal and sigmoid colon serrated lesions >5 mm in size were reviewed by an experienced GI pathologist.
Main Outcome Measurements: Prevalence of SSA/Ps, defined as the proportion of patients with ≥1 SSA/P.
Results: There were 1910 patients, of whom 389 had 656 lesions in the serrated class. Review by the experienced GI pathologist determined a prevalence of SSA/Ps without cytologic dysplasia of 7.4% and SSA/Ps-CD of 0.6% (total SSA/P prevalence 8.1%). SSA/Ps and SSA/Ps-CD comprised 5.6% and 0.3%, respectively, of all resected polyps. The mean size of SSA/Ps was 7.13 mm (standard deviation [SD] 4.66), and 51 of 77 (66.2%) polyps ≥10 mm in the serrated class were SSA/Ps.
Limitations: Retrospective design.
Conclusion: A colonoscopist with a high lesion detection rate and an experienced pathologist identified a high prevalence (8.1%) of SSA/Ps in a screening population. SSA/Ps are more common than previously believed.
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| http://dx.doi.org/10.1016/j.gie.2014.04.064 | DOI Listing |
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