AI Article Synopsis
- The organization of chromatin in the nucleus is crucially linked to how genes are transcribed, with recent research revealing mechanisms that clarify this connection.
- Changes in chromatin organization correspond to shifts in cell identity, illustrating a hierarchical structure in the genome that influences gene regulation.
- Key factors like Cohesin, CTCF, and Mediator are essential for this process, showing that both chromatin organization and gene regulation are interdependent in defining and maintaining cell identity throughout development.*
Article Abstract
The organization of chromatin within the nucleus and the regulation of transcription are tightly linked. Recently, mechanisms underlying this relationship have been uncovered. By defining the organizational hierarchy of the genome, determining changes in chromatin organization associated with changes in cell identity, and describing chromatin organization within the context of linear genomic features (such as chromatin modifications and transcription factor binding) and architectural proteins (including Cohesin, CTCF, and Mediator), a new paradigm in genome biology was established wherein genomes are organized around gene regulatory factors that govern cell identity. As such, chromatin organization plays a central role in establishing and maintaining cell state during development, with gene regulation and genome organization being mutually dependent effectors of cell identity.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125518 | PMC |
| http://dx.doi.org/10.1016/j.gde.2014.05.002 | DOI Listing |
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